Allergy to topical medications
What are topical medications?
Topical medications include balms, creams, gels, oils, lotions, patches, ointments and other products that you apply to your skin. They are made up of an active ingredient and base which may contain preservatives and fragrances. Many topical formulations are available over-the-counter and include products such as antibacterial and antifungal preparations, anti-inflammatory and pain-relief preparations, and cleansing and moisturising agents.
What is allergy to topical medications?
An allergy to a topical medication can produce a range of reactions.
|Irritant contact dermatitis||
|Allergic contact dermatitis||
Some people may suffer from one or more reactions. In particular, atopic individuals (patients with atopic eczema, asthma and/or rhinitis) are more prone to irritant contact dermatitis, which in turn increases their likelihood of allergic contact dermatitis as their skin barrier function is weakened and more sensitized to the allergen.
What are the allergens in topical medications?
Allergens found in topical medications may be the active drug ingredient or a component of the vehicle or base that carries the drug.
Drug allergens found in topical formulations that have been known to cause allergic skin reactions include:
- Neomycin – antibiotic that is used widely in topical creams, ointments, lotions, eye preparations and eardrops. These prescription and non-prescription preparations are used to treat a variety of skin, eye and external ear disorders.
- Corticosteroids – anti-inflammatory agents used in the treatment of many conditions and diseases. There are many different types of topical corticosteroids with varying potencies and actions. They are also commonly found in combination preparations with antibacterials and antifungal agents.
- Benzocaine – widely used local anaesthetic often used topically. Doctors and dentists use benzocaine preparations, especially on mucosal surfaces such as the mouth, to prepare or 'numb' a site for injection. Local anaesthetics such as Benzocaine are also found in some haemorrhoidal preparations
- Salicylate – is a chemical found naturally in plants and is the main ingredient of the pain relieving tablet, aspirin. It is used in muscle pain creams.
- Non-steroidal anti-inflammatory drugs – these are used in topical gels and creams to treat muscle and joint pain.
Am I allergic to topical medications?
Allergy to topical medications is diagnosed by performing special allergy tests, i.e. patch tests. Diagnosis may involve testing against the active drug ingredient or a component of the base. See individual contact allergens for patch testing recommendations.
It appears that allergy to topical medications is more common in elderly patients. A study of all patients patch tested at a Sheffield hospital over 9 years confirmed that contact allergy to topical medicaments is more common in those aged more than 70 years compared with the younger age groups.
Some patients with pre-existing skin conditions may be more at risk of developing allergic reactions to topically applied medications.
- Individuals with venous stasis dermatitis are at high risk for developing allergy to agents applied to the affected area. Topical neomycin is an important cause of allergic contact dermatitis in these patients because it is used frequently despite the lack of documentation of its efficacy in the treatment of stasis ulcers.
- Patients with otitis externa are often allergic to topical neomycin and topical corticosteroids.
What is the treatment for allergy to topical medications?
Contact dermatitis should clear rapidly once the offending allergen is removed. In cases where the allergen is not a topical corticosteroid, over-the-counter mild topical steroids, such as hydrocortisone 0.5-2.5%, may be used to help control itching, swelling, and redness. In more severe cases, a prescription steroid cream may be required, as well as antibiotic medication if the skin becomes blistered and infected (impetiginised).
Care needs to be taken when prescribing topical medications to elderly patients with eczema, especially for preparations that contain perfumes, lanolins (wool alcohols), and local anaesthetics as these are the allergens most commonly associated with allergic skin reactions in this group of patients.
Your dermatologist may have further specific advice, particularly if you are highly sensitive to particular allergens.
- Green CM, Holden CR, Gawkrodger DJ. Contact allergy to topical medicaments becomes more common with advancing age: an age-stratified study. Contact Dermatitis 2007;56(4):229-31
- Skin Allergies – WebMD.com
On DermNet NZ:
- Allergic contact dermatitis – Medscape Reference, the online textbook
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See the DermNet NZ bookstore