Indications for phototherapy
- List common skin diseases that may be treated with phototherapy and photodynamic therapy
- Describe patient factors that impact on phototherapy
In general, the same skin diseases may be treated with phototherapy using UVB or photochemotherapy (PUVA). The most common conditions treated include:
- Atopic dermatitis
- Other forms of dermatitis
Other less common indications include:
- Alopecia areata
- Pityriasis rosea
- Cutaneous T-cell lymphoma (CTCL)
- Polymorphous light eruption & other photodermatoses
- Lichen planus
- Generalised pruritus
- Pityriasis lichenoides
Many other skin diseases may also respond to treatment.
Photodynamic therapy (PDT) has recently been introduced to New Zealand. The main indications are actinic keratoses, in-situ squamous cell carcinoma and superficial basal cell carcinoma. PDT may prove useful for other skin diseases as experience is gained.
UVA1 phototherapy is not available in New Zealand. It is mainly used for atopic dermatitis, systemic sclerosis, morphoea, urticaria pigmentosa, disseminated granuloma annulare, lichen sclerosus, CTCL and graft-versus-host disease.
Extracorporeal photopheresis is not available in New Zealand. It is mainly used for erythrodermic CTCL (Sézary syndrome) & chronic graft-versus-host disease but has also been successfully applied to autoimmune diseases such as systemic sclerosis, pemphigus and connective tissue disease.
The initial assessment of the patient should include evaluation of:
- Age, sex, social & economic factors
- The skin disease
- Current and prior treatment
- Current medical problems
UVB phototherapy is contraindicated in infants but may be recommended for severe disease in children. PUVA is contraindicated in young children and rarely recommended prior to adulthood because it is known to cause skin cancer.
Either form of phototherapy may be impractical in the very elderly.
Females of childbearing age should be assessed for the risk of pregnancy and need for contraception. UVB phototherapy is permitted in pregnancy. PUVA is relatively contraindicated in pregnancy and absolutely contraindicated in breastfeeding.
Social & economic factors
The patient must be in a position to attend regularly for the full course of treatment, which may require three scheduled visits each week in working hours for many weeks or months. Intelligence, distance from the treatment centre, occupation and cost of treatment may be barriers.
Assess the individual's perception of the disease and its psychosocial effect.
Phototherapy has risks and side effects and may be inconvenient and expensive. The severity of disease or disability arising from it must warrant the treatment.
Severity may relate to:
- Extent of the skin disorder
- Involvement of specific sites such as face, hands & feet
- Symptoms such as itch or soreness
- Psychosocial impact
The disease should be located on exposed and relatively hairless skin.
A history of photo-aggravated skin disease or another adverse reaction to sunlight or previous phototherapy should be considered carefully, and may or may not be a contraindication to cautious treatment.
Other possible topical or systemic treatments may be selected instead of or as well as phototherapy.
Current & prior treatment of skin disease
Consider whether the current or prior treatment increases the risk of phototherapy.
- Prolonged &/or frequent courses of UVB or PUVA. More than 120-200 treatments with PUVA are a relative contraindication to further treatment.
- Immunosuppressive agents. Azathioprine and ciclosporin in particular markedly increase the risk of photocarcinogenesis and are contraindications to phototherapy.
- Photosensitising oral medications eg acitretin, which is frequently combined with phototherapy and necessitates lower initial doses.
- Photosensitising topical medications eg tar, which can be used but must be removed prior to exposure and lower initial doses should be selected.
Current medical problems
A careful history should include assessment of the following conditions:
- Cardiovascular disease: the patient may need to stand unassisted in a hot environment for 10 minutes or longer. Consider whether this is practical or hazardous to the patient.
- Active or latent lupus erythematosus is a contraindication to phototherapy or PUVA.
- Severe renal or hepatic disease may be a contraindication to PUVA.
- Pregnancy: consider the effect of treatment on the fetus. Avoid PUVA where possible.
- Sun damage: prior skin cancers are a relative contraindication to phototherapy. It should be used only in exceptional circumstances if a patient has a history of multiple skin cancers or melanoma. Facial skin should be protected from exposure. Additional acitretin may reduce the risk.
- Eye disease: very careful eye protection is mandatory for all patients. Contact their ophthalmologist if a patient has significant eye disease (cataracts, keratitis etc).
Topical & oral photosensitisers
Prescribed and over-the-counter cosmetics, topical and systemic medications may be photosensitising, i.e. a relatively low dose of ultraviolet radiation may provoke erythema, an eczematous dermatitis or other rash. In most cases, phototherapy is still possible, but if a photosensitising medication has been identified, it should be avoided or lower initial doses should be used.
Topical photosensitising agents include:
- Coal tar and its derivatives
- Plants (especially umbelliferae) and derivatives such as essential oils & fragrances
- Sunscreens (rarely)
The most common oral photosensitising medications include:
- Thiazide diuretics
- Antibiotics especially tetracyclines, quinolones & sulphonamides
- Non-steroidal anti-inflammatory drugs
- Nalidixic acid
- St John's Wort
There are others.
Absolute contraindications to phototherapy or photochemotherapy are:
- Xeroderma pigmentosum
- Lupus erythematosus
- Breastfeeding (photochemotherapy only)
Create a proforma for patient assessment prior to phototherapy.
On DermNet NZ:
Information for patients
- Photosensitizing Medication List – Radiation Protection Services, Oregon.gov
Books about skin diseases:
See the DermNet NZ bookstore