The medical term for hair loss is alopecia. Alopecia may be localised or diffuse. Patients may notice hair shedding, poor hair quality, hair thinning or bald areas. There may be associated scalp disease or scarring.
Dermatologists comment that scalp hair loss seems to provoke more distress than many severe skin conditions. Unfortunately, hair loss may not be easy to remedy.
What causes hair loss?
Hair loss can be due to:
- Decreased growth of the hair
- Increased shedding of the hair
- Breakage of hairs
- Conversion of thick terminal hairs to thin vellus hairs
Hair grows in a cycle: anagen (living growing hair), catagen (in-between phase) and telogen (resting or falling-out phase). Recently a new phase, ketogen, has been recognised; this is when the follicle is empty, after the telogen hair has fallen out and before the anagen hair is visible on the scalp.
Image © 1998 Merck Sharpe & Dohme (with permission)
Anagen hair loss
Anagen normally lasts two to seven years. Hair loss occurs when anagen is interrupted by certain medications (e.g. anti-cancer drugs), or by the ‘autoimmune’ disease, alopecia areata. This form of hair loss is known as anagen effluvium. Anagen hair is tapered or broken-off.
Hair shedding during chemotherapy
Hair lost through chemotherapy
Telogen hair loss
Telogen lasts a few months and is terminated by a new anagen hair. The result is shedding a hair with a bulb at the end (club hair). It is normal to lose 50 or more telogen hairs a day, rather more in autumn and winter. Excessive shedding results in telogen effluvium, often a couple of months after an event such as child-bearing, fever, an operation, weight loss or certain medications. Sometimes there appears to be no recognisable cause, and the shortened hair cycle can continue for years (chronic telogen effluvium).
New growth can be seen at the hairline as a sign of recovery.
Pattern hair loss (androgenetic alopecia)
Genetic and hormonal influences result in gradual thinning of scalp hair with age as male or female pattern (androgenetic) hair loss. In some families this type results in male pattern alopecia and in others, considerable thinning in females (female pattern alopecia). It is apparent in about 50% of individuals by the age of 50 years.
Male pattern balding
Female pattern balding
Severe female pattern balding
Other causes of hair loss are associated with poor quality hair:
- Iron deficiency
- Deficiency of thyroid hormone
Replacement of iron or thyroid hormone respectively may result in prompt regrowth.
Hair shaft abnormality
If hair loss first occurs in childhood, it may be due to a genetic hair shaft defect. These are diagnosed by microscopic examination of the hair, and sometimes by scanning electron microscopy. A large number of different types of hair shaft abnormaility have been described, including:
- Fractures: trichorrhexis nodosa, trichoschisis, trichoclasis (trichothiodystrophy)
- Irregularities: trichorrhexis invaginata (seen with ichthyosis in Netherton's syndrome), Marie-Unna hypotrichosis (uncombable hair), pili bifurcati, pili annulati, pseudopili annulati, monilethrix (beaded hair), pseudomonilethrix
- Coiling and twisting: pili torti (twisted hair), woolly hair, trichonodosis (knotted hair)
Anagen hair loss in a child may be due to ‘loose anagen syndrome’. Clumps of hair come out with combing. The hair loss gradually becomes less as the child becomes an adult.
Trauma, infection and various skin diseases may injure the hair follicle resulting in localised areas of scarring and bald patches in which there are no visible follicles; this is called ‘cicatricial alopecia’.
Skin diseases that may cause cicatricial alopecia include folliculitis decalvans, lichen planopilaris, frontal fibrosing alopecia, alopecia mucinosa, discoid lupus erythematosus and scleroderma. Scarring hair loss of unknown cause is known as pseudopelade of Brocq.
Discoid lupus erythematosus
Although scalp infections may cause permanent balding if neglected, early treatment of staphylococcal infections (impetigo and boils or abscesses), tinea capitis and kerion prevents permanent baldness.
Hair loss caused by psoriasis, in which there are thick plaques of scale, recovers once the skin condition is controlled. Seborrhoeic dermatitis or atopic dermatitis can sometimes also cause hair loss.
Psoriasis © R Suhonen
Hair can be pulled out by tight curlers or certain hair styles, sometimes resulting in permanently thinned areas (traction alopecia). The hair shafts can be broken by heat (hair dryer), or chemicals (perming solution or bleach) or brushing too often. Hair practices that apply traction to the hair constantly may cause permanent hair loss, for example, central centrifugal cicatricial alopecia.
Image supplied by Dr John Adams
- Diagnosing and Treating Hair Loss – Am Fam Physician. 2009 Aug 15;80(4):356-362.
On DermNet NZ NZNZ:
- Alopecia areata
- Male pattern hair loss
- Female pattern hair loss
- Telogen effluvium
- Hair shaft defects
- Short anagen syndrome
- Alopecia mucinosa
- Alopecia from drugs
- Hair replacement
- Lichen planopilaris
Other web sites:
- Hair Diseases and Hair Loss – Medline Plus
- Cicatricial Alopecia Research Foundation
- Help with Hair Loss – Am Fam Physician. 2009 Aug 15;80(4):373-374.
- Medscape Reference
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