Eccrine spiradenoma – pathology
This distinctive tumour is an adnexal tumour argued to arise from the apocrine or eccrine secretory coil or coiled duct.
Histology of eccrine spiradenoma
Low power view of eccrine spiradenoma shows a well circumscribed tumour nodule arising within the dermis or superficial subcutis. The tumour is comprised of a diffuse dense basophilic cellular proliferation (Figures 1 and 2). In some cases a prominent vascular component can be seen (Figures 2 and 3). Eosinophilic hyaline deposits are seen in amongst the tumour cells as droplets and bands (Figure 4). A lymphocytic infiltrate is seen and when heavy can mimic lymphoid tissue.
Variants of eccrine spiradenoma pathology
Brooke-Spiegler syndrome: No differences are seen between sporadic eccrine spiradenoma or those occurring in the context of this syndrome. Tumours with overlap features with eccrine spiradenoma can be seen.
Differential diagnosis of eccrine spiradenoma pathology
Cylindroma: In this tumour the low power view shows discrete polygonal tumour islands. There is frequently a more prominent population of S100 positive dendritic cells while in Eccrine Spiradenoma there is a minor lymphocytic infiltrate present,.
Spiradenocylindroma: In some tumours features of both cylindroma and eccrine spiradenoma can be seen and are designated as overlap tumours.
Cutaneous lymphadenoma: In this tumour there is a lobular tumour of basaloid cells which may show peripheral palisading and a dense mixed inflammatory cell infiltrate though predominantly lymphocytic.
- Skin Pathology (2nd edition, 2002). Weedon D
- Pathology of the Skin (3rd edition, 2005). McKee PH, J. Calonje JE, Granter SR
- Immunohistochemical differentiation of four benign eccrine tumors. Missall TA, Burkemper NM, Jensen SL, Hurley MY. J Cutan Pathol. 2009 Feb;36(2):190-6.
- Expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis. Mahalingam M, Srivastava A, Hoang MP. Am J Dermatopathol. 2010 Dec;32(8):774-9.
On DermNet NZ:
Books about skin diseases:
See the DermNet NZ bookstore