Punctate-type palmoplantar keratoderma
What are punctate keratodermas?
Punctuate keratodermas result in tiny bumps of thickened skin on the palms and soles and usually appears in late childhood or early adulthood.
What causes punctate keratodermas?
Punctate keratodermas are inherited by an autosomal dominant pattern (the abnormal gene is passed on from an affected parent). Some people with filiform keratoderma have no apparent family history of the condition.
What are the different types?
There are three different types of punctuate-type keratoderma:
- Punctate keratoderma: tiny hard rounded bumps in the palms or soles.
- Filiform keratoderma: tiny hard ‘spikes’ of skin growing out of the skin of the palms and soles and sometimes elsewhere on the skin.
- Marginal keratoderma: tiny bumps along the border of the palms and fingers, soles and toes.
Image from Dr Marcia Sonneveld
Treatment of punctate keratoderma
The following treatments soften the thickened skin and make them less noticeable.
- Keratolytics (e.g. 6% salicylic acid in 70% propylene glycol)
- Topical retinoids
- Topical vitamin D ointment (calcipotriol)
- Systemic retinoids (acitretin)
What is the prognosis?
These conditions persist for life and may be passed on to the next generation. General health is not affected although the thickened skin can interfere with activity.
- OMIM – Online Mendelian Inheritance in Man (search term Punctate-type palmoplantar keratoderma)
On DermNet NZ:
- Palmoplantar keratoderma (introduction)
- Hereditary diffuse palmoplantar keratoderma
- Hereditary focal palmoplantar keratoderma
- Acquired keratoderma
- Cracked heels
- Keratosis Palmaris et Plantaris – Medscape Reference
Books about skin diseases:
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