Actinic cheilitis

Author: Dr Mark Duffill, Dermatologist, Hamilton, NZ, 2008. Updated by Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand. December 2015.

What is actinic cheilitis?

Actinic cheilitis presents as diffuse or patchy dryness and variable thickening of the vermilion of the lower lip. The common form of actinic cheilitis is due to chronic sun exposure. It is also called actinic cheilosis, solar cheilitis, and sometimes, actinic cheilitis with histological atypia.

Actinic cheilitis also describes lip involvement in actinic prurigo, a rare form of photosensitivity.

Who gets actinic cheilitis?

Actinic cheilitis mainly affects adults with fair skin who live in tropical or subtropical areas, especially outdoor workers. They often recall having sunburned lips in earlier years. They may also have actinic keratoses on other sun exposed sites of the scalp, ears, face and hands.

Actinic cheilitis is three times more common in males than in females.

What causes actinic cheilitis?

Actinic cheilitis results from chronic exposure of the lower lip to solar ultraviolet radiation. It is more vulnerable than surrounding skin because mucosal epithelium is thinner and less pigmented than the epidermis.

What are the clinical features of actinic cheilitis?

Actinic cheilitis most commonly affects the lower lip (90%), and causes:

Less common features of actinic cheilitis include:

What are the complications of actinic cheilitis?

Actinic cheilitis is a pre-malignant condition. It predisposes to:

Cancer of the lip is more common in smokers than in non-smokers. Other factors include oncogenic human papillomavirus (wart virus), alcohol abuse and immunosuppression.

Invasive squamous cell carcinoma should be suspected if the lip is focally tender, or a persistent ulcer or enlarging nodule develops.

How is actinic cheilitis diagnosed?

Actinic cheilitis is usually diagnosed clinically. A skin biopsy may be taken if skin cancer or an inflammatory cause of cheilitis is suspected.

The pathological features of actinic cheilitis are variable thickening or atrophy of the lip, partial thickness epidermal dysplasia, solar elastosis and inflammation in the dermis.

What is the treatment for actinic cheilitis?

Smoking cessation and lifelong, year-round, daily sun protection are essential.

Men can consider growing a moustache.

Topical therapies for actinic cheilitis are unapproved. They include:

Physical treatments for actinic cheilitis include:

How can actinic cheilitis be prevented?

Actinic cheilitis can be prevented by protecting the lips from sun exposure. In smokers, the risk of cancer can be reduced by smoking cessation.

What is the outlook for actinic cheilitis?

Actinic cheilitis can improve with effective sun protection and treatment. Continued sun exposure and lack of treatment increase the risk of squamous cell carcinoma, which is potentially life threatening.

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