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Angiomyofibroblastoma pathology

Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.

Angiomyofibroblastoma is a benign soft tissue tumour of the external genitalia.

Histology of angiomyofibroblastoma

Microscopic examination of angiomyofibroblastoma demonstrates a well-circumscribed tumour without a capsule and with variable cellularity. Hypocellular areas are collagenous (figure 1) or myxoid with some small-medium sized vessels. Hypercellular areas, located predominately around the vessels, contain characteristic plump round/oval shaped cells with relatively uniform nuclei without remarkable atypia (figure 2). Occasional multinucleated and binucleated cells may be seen.

Special studies for angiomyofibroblastoma

The angiomyofibroblastoma tumour cells are positive with immunohistochemistry for actin. Estrogen and progesterone markers may also be positive.

Differential diagnosis of angiomyofibroblastoma pathology

Aggressive angiomyxoma – These are infiltrative tumours and usually much larger (more than 5cm). Tumours have been described with mixed features of angiomyofibroblastoma and aggressive angiomyxoma, which raises the possibility that these tumours are related.

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