Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.
AcuteGeneralisedExanthematous Pustulosis (AGEP) is a rare dermatosis that presents as multiple pustules on a generalized erythematous eruption. Numerous causative drugs and infections have been implicated.
Histology of AGEP
In AGEP, there is spongiosis and minimal acanthosis of the epidermis. Neutrophilicspongiotic pustules are the most striking feature (figure 1, 2). These pustules are present within the stratum corneum and/or the epidermis. Sometimes, apoptotic keratinocytes are seen in the adjacent epidermis. There is often a dermal response which is rich in lymphocytes and eosinophils (figure 3).