Adams-Oliver syndrome

Author: Brian Wu PhD. MD Candidate, Keck School of Medicine, Los Angeles, USA; Chief Editor: Hon A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand, February 2016.

What is Adams-Oliver syndrome?

Adams-Oliver syndrome is a rare condition characterised by various malformations of the limbs and abnormal skin development, particularly on the scalp.

Adams-Oliver syndrome is also known as:

Who gets Adams-Oliver syndrome?

Adams-Oliver syndrome is considered to be very rare, with an incidence of about 1 in 225,000 live births. The aetiology is unknown. However:

What causes Adams-Oliver syndrome?

Adams-Oliver syndrome is caused by genetic mutations in at least 6 genes: 

What are the clinical features of Adams-Oliver syndrome?

The primary features of Adams-Oliver syndrome include: 

Diagnosis is based on clinical signs and symptoms, patient/family history and imaging.

What is the treatment for Adams-Oliver syndrome?

There is no cure for Adams-Oliver syndrome; treatment focuses in on symptom management and can include:

What is the outcome for Adams-Oliver syndrome?

Long-term prognosis for Adams-Oliver syndrome is difficult to predict: it is not adequately described in medical literature due to a dearth of cases. 

It should be noted that, in absence of major abnormalities, those with this condition should have a normal lifespan.

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