Cobb syndrome

Author: Brian Wu, MD candidate, Keck School of Medicine, Los Angeles, USA. DermNet New Zealand Editor in Chief: Hon A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. December 2016.

What is Cobb syndrome?

Cobb syndrome is characterised by vascular lesions and neurological deficits. It is also known as spinal arteriovenous metameric syndrome (SAMS) and cutaneous meningospinal angiomatosis.

While first described by Berenbauch in 1890, the syndrome is most closely associated with Dr Cobb’s description of a clinical case in 1915.

Who gets Cobb syndrome?

Cobb syndrome is an extremely rare disorder.

What causes Cobb syndrome?

The cause of Cobb syndrome is not completely understood. It is believed that somatic mutations in the neural crest or mesoderm are responsible for its development fairly early in the development of the embryo .

What are the clinical signs of Cobb syndrome?

Cobb syndrome presents with multiple vascular lesions:

Signs of neurological involvement include:

If neurological symptoms do occur, they can happen in intermittent episodes, gradual progression, or with sudden onset.

Structural abnormalities of the urinary tract are also reported.

What are the complications of Cobb syndrome?

Possible complications include:

How is Cobb syndrome diagnosed?

Cobb syndrome is diagnosed by the presence of multiple cutaneous vascular lesions and neurological defects. Spinal vascular lesions associated with Cobb syndrome can be diagnosed by MRI, although CT scans, radiography, or angiography can also be used for detection.

How is Cobb syndrome treated?

Treatment for Cobb syndrome may include:

What is the outlook for Cobb syndrome?

The outlook for children with Cobb syndrome is dependent upon:

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