Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.
Condylomas are usually sexually transmitted lesions caused by Human papillomavirus (HPV).
Histology of condyloma acuminatum
Histopathologic examination of condyloma acuminatum reveals epidermal acanthosis. The surface has an undulated rounded papillomatosus rather than the spiked verrucoushyperplasia seen in verruca vulgaris (figure 1).
High power examination of condyloma acuminatum usually reveals vacuolated keratinocytes with shrunked nuclei (koilocytes) in the upper layers of the epidermis (figure 2). There may be enlarged keratohyaline granules as seen in other HPV-induced lesions.