Cutaneous lymphadenoma disease pathology

Author: A/Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2014.

Cutaneous lymphadenoma is a follicular tumour that presents as a small dermal papule. They are regarded by many authors as a form of trichoblastoma.

Histology of lymphadenoma

In cutaneous lymphadenoma, there is a well circumscribed dermal mass composed of large tumour islands. The surrounding stroma is fibrotic and is intimately connected to the epithelial islands (figures 1, 2). The islands are infiltrated by impressive populations of lymphocytes (figures 1–3). There is peripheral palisading surrounding the basaloid follicular cells which make up the tumour islands.

Cutaneous lymphadenoma pathology

Special stains for cutaneous lymphadenoma

None are generally needed. The lymphocytes have been studied and have been shown to be a mixture of CD3 positive T-cells and CD20 positive B-cells.

Differential diagnosis of cutaneous lymphadenoma

The infiltrating lymphocytes are highly distinctive for cutaneous lymphadenoma. Without these, the diagnosis is that of a trichoblastoma.

Basal cell carcinoma will show retraction, irregular growth and there is a lack of the intimate relationship between the epithelium and surrounding stroma seen in benign follicular tumours.

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Related information



  • Alsadhan A, Taher M, Shokravi M. Cutaneous lymphadenoma. J Am Acad Dermatol. 2003 Dec;49(6):1115-6.
  • Pathology of the Skin (Fourth edition, 2012). McKee PH, J. Calonje JE, Granter SR

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