Author: A/Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2014.
Eccrine spiradenocarcinoma is a rare sweat gland tumour. It typically arises within a pre-existing eccrine spiradenoma that has been present for many years.
Histology of eccrine spiradenocarcinoma
In eccrine spiradenocarcinoma, sections show a areas of benign eccrine spiradenoma with an abrupt transition in morphology (figures 1, 2). The malignant areas can be carcinomatous or sarcomatous. The carcinoma typically shows marked nuclear pleomorphism, atypia and mitoses (figures 2, 3).
A low grade form has also been decribed in which the tumour cells show lesser nuclear atypia but the usual architecture of eccrine spiradenoma is lost, there are increased mitoses and often infiltration of surrounding structures.