Eccrine spiradenoma pathology

Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, 2011.


Eccrine spiradenoma pathology — codes and concepts
open

Introduction

This distinctive tumour is an adnexal tumour argued to arise from the apocrine or eccrine secretory coil or coiled duct.

Histology of eccrine spiradenoma

Low power view of eccrine spiradenoma shows a well-circumscribed tumour nodule arising within the dermis or superficial subcutis. The tumour is comprised of a diffuse dense basophilic cellular proliferation (Figures 1 and 2). In some cases a prominent vascular component can be seen (Figures 2 and 3). Eosinophilic hyaline deposits are seen in amongst the tumour cells as droplets and bands (Figure 4). A lymphocytic infiltrate is seen and when heavy can mimic lymphoid tissue.

Eccrine spiradenoma pathology

Variants of eccrine spiradenoma pathology

Brooke-Spiegler syndrome — no differences are seen between sporadic eccrine spiradenoma or those occurring in the context of this syndrome. Tumours with overlap features with eccrine spiradenoma can be seen.

Differential diagnosis of eccrine spiradenoma pathology

Cylindroma — in this tumour the low power view shows discrete polygonal tumour islands. There is frequently a more prominent population of S100 positive dendritic cells while in eccrine spiradenoma there is a lymphocytic infiltrate.

Spiradenocylindroma — some tumours features of both cylindroma and eccrine spiradenoma can be seen and are designated as overlap tumours.

Cutaneous lymphadenoma — in this tumour there is a lobular tumour of basaloid cells which may show peripheral palisading, and a dense mixed inflammatory cell infiltrate though predominantly lymphocytic.

 

Related information

 

References

  • Skin Pathology (2nd edition, 2002). Weedon D
  • Pathology of the Skin (3rd edition, 2005). McKee PH, J. Calonje JE, Granter SR
  • Missall TA, Burkemper NM, Jensen SL, Hurley MY. Immunohistochemicaldifferentiation of four benign eccrine tumors. J Cutan Pathol. 2009 Feb;36(2):190-6. doi: 10.1111/j.1600-0560.2008.00991.x. Epub 2008 Jun 17. PubMed PMID: 18564284.
  • Mahalingam M, Srivastava A, Hoang MP. Expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis. Am J Dermatopathol. 2010 Dec;32(8):774-9. doi: 10.1097/DAD.0b013e3181dafd8c. PubMed PMID: 20700038.

On DermNet NZ

Books about skin diseases

See the DermNet NZ bookstore.