Author: A/Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2014.
Also known as floridpapillomatosis and papillary adenoma, these lesions present as nipple erythema or nodules which may mimic mammary Paget disease.
Histology of erosivepapillomatosis of the nipple
In erosivepapillomatosis of the nipple, sections show a papillary epithelialproliferation which connects with the overlying epidermis (figure 1). The lesion consists of fibrovascular cores lined by bland cells (figure 2). The cells are usually at least 2 layers thick and consist of a myoepithelial layer and an epithelial layer which may exhibit apocrine differentiation (figure 3)
Special studies of erosivepapillomatosis of the nipple
None are generally needed.
Differential diagnosis of erosivepapillomatosis of the nipple
Carcinoma – Breast carcinoma invading the nipple will show more nuclear atypia, usually lack a papillary growth pattern and lacks the dual myoepithelial/epithelial lining.
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Weedon’s Skin Pathology (Third edition, 2010). David Weedon
Pathology of the Skin (Fourth edition, 2012). McKee PH, J. Calonje JE, Granter SR