Graft versus host disease

Author: Vanessa Ngan, Staff Writer, 2003.

What is graft versus host disease?

Graft versus host disease (GVHD) is a condition where following transplantation the donor's immune cells in the transplant (graft) make antibodies against the patient's tissues (host) and attack vital organs. Organs most often affected include the skin, gastrointestinal (GI) tract and the liver.

Ninety percent of bone marrow transplants lead to GVHD. Solid organ transplantation, blood transfusions, and maternal-fetal transfusions have also been reported to cause GVHD less frequently.

Types of GVHD

There are two forms of GVHD.

What are the signs and symptoms of GVHD?

Acute GVHD and chronic GVHD are distinct diseases. One common factor is that they both increase the patient's susceptibility to infection.

Acute GVHDChronic GVHD
  • Tender, red spots usually appear 10-30 days post transplantation
  • Face, hands and feet affected first then spreading to whole body (erythroderma)
  • Spots may coalesce to form widespread red rash
  • Rash may develop into raised spots or blisters that resemble toxic epidermal necrolysis
  • Fever may be present
  • Watery or bloody diarrhoea with stomach cramps indicates GI involvement
  • Jaundice (yellowing of the skin and eyes) indicates liver involvement
  • Abnormal liver function tests
  • Dry, itchy raised rash develops over whole body
  • Dry mouth and sensitivity to spicy or acid foods leading to mouth lesions
  • Dry eyes causing irritation and redness
  • Skin thickening, scaling, hyper- or hypopigmentation (resembling lichen planus)
  • Loss of skin colour without thickening (vitiligo)
  • Hardening of skin (scleroderma) may interfere with joint mobility
  • Hair loss (including typical alopecia areata) or premature greying
  • Genital disease, including painful vulval and vaginal ulceration with scarring
  • Decreased sweating
  • Liver involvement causing jaundice
  • Lung and GI disorders may occur

What is the treatment of GVHD?

Patients recovering from bone marrow transplantation are usually hospitalised for several weeks following transplant and are monitored closely for signs of developing GVHD or infection. The best treatment for GVHD is prevention. This consists of a cocktail of immunosuppressive drugs such as:

The combination of ciclosporin and methotrexate has been found to significantly decrease the severity of GVHD. These drugs weaken the ability of the donor's immune cells to launch an attack on the patient's organs.

Treatment for patients who do develop GVHD depends on the severity of the disease. Mild cases with only skin involvement of acute GVHD may settle without treatment. More severe acute or chronic GVHD predisposes the patient to infection and overwhelming sepsis (blood poisoning) is the main cause of death in patients with GVHD. The aim is to treat GVHD before life-threatening sepsis occurs.

Because GVHD affects so many different organs, treatment is usually delivered by a multi-disciplinary team of transplant doctors, dermatologists, respiratory doctors, gastroenterologists, ophthalmologists, and/or other specialists.

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