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Author: Adjunct A/Prof Patrick Emanuel, Dermatopathologist, Clinica Ricardo Palma, Lima, Peru. DermNet NZ Editor-in-chief: Adjunct A/Prof Amanda Oakley. August 2018.
In intralymphatic histiocytosis, the histopathology shows dilated lymphatic spaces stuffed with histiocytes and associated lymphocytes (figures 1,2,3). There is often oedema of the surrounding dermis. The overlying epidermis is uninvolved. In cases occurring around the eyes, it is common to find Demodex species in follicular structures (figure 4).
Immunohistochemical studies for lymphatics (eg, D2–40) highlight the lymphatic structures. Histiocyte markers (eg, CD68, CD143) highlight the histiocytes.
Emanuel PO, Lewis I, Gaskin B, Rosser P, Angelo N. Periocular intralymphatic histiocytosis or localized Melkersson-Rosenthal syndrome? J Cutan Pathol. 2015 Apr;42(4):289-94. doi: 10.1111/cup.12419. Epub 2015 Feb 3. PubMed PMID: 25370527. Journal.
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