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Author: Anoma Ranaweera B.V.Sc; PhD (Clinical Biochemistry, University of Liverpool, UK); Chief Editor: Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand, June 2016.
In March 2016, the US FDA approved Ixekizumab (TALTZ™ Eli Lilly, Indiana, USA) for the treatment of psoriasis. In November 2017, they also approved it for active psoriatic arthritis.
In April 2016, the European Medicines Agency also granted marketing authorization of ixekizumab for treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy.
Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) with neutralizing activity against IL-17A. It is produced by recombinant DNA technology in a mammalian cell line and is comprised of two identical light chain polypeptides of 219 amino acids each and two identical heavy chain polypeptides of 445 amino acids each.
Ixekizumab is used for treating moderate to severe plaque psoriasis in adult patients thtat are candidates for systemic therapy (medicine absorbed into the blood stream) or phototherapy (ultraviolet light treatment). It has also been demonstrated to improve scalp psoriasis and nail psoriasis.
Potential drug interactions with ixekizumab
Ixekizumab is very well tolerated. Most common (≥1%) adverse reactions associated with ixekizumab treatment are:
Less common adverse reactions (<1%) include:
The safety and effectiveness of ixekizumab has not been established in paediatric patients (<18 years of age).
Clinical studies of ixekizumab did not include sufficient numbers of patients aged 65 years and older to determine whether they respond differently from younger patients.
No formal studies have been conducted on the effect of hepatic or renal impairment on the pharmacokinetics of ixekizumab
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