Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, 2011.
Histology of necrobiosis lipoidica
Scanning power view of necrobiosis lipoidica demonstrates a layered inflammatory process and alternating zones of necrobiosis involving the full thickness of the dermis (Figure 1). The changes tend to become more pronounced deeper in the dermis and may extend into the septal panniculus (Figures 2 and 3). The areas of necrobiosis are poorly defined and run into each other with broad foci of inflammatoryinfiltrate intervening (Figure 4). This may form a stacked ‘lasagne’ type appearance. A variable histiocyticinfiltrate with multinucleatedgiant cells surrounds these areas. The accompanying inflammatoryinfiltrate is predominantly lymphocytic with plasma cells and occasional eosinophils (Figure 5). As lesions age an increasing degree of dermalfibrosis is seen.
Granuloma annulare: In this condition the areas of necrobiosis are better defined with dermal sparing between these granulomatous foci. Plasma cells are more commonly a feature of necrobiosis lipoidica.
Necrobiotic xanthogranuloma: Here there is a more prominent foamy histiocyticinfiltrate with numerous touton and foreign body type giant cells. Cholesterol clefts favour this condition but have been reported also in necrobiosis lipoidica. When in doubt the clinical details are usually discriminatory.
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