DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages
Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.
In orofacial granulomatosis, sections show oral mucosa with a sparse inflammatory infiltrate and mild oedema (figure 1). Higher power examination shows ectasia of lymphatics next to rare loose granulomas (figures 2-4, arrows indicate granulomas). Sometimes the granulomas may be difficult to find and extensive serial sectioning of the biopsy is recommended.
Special stains for microorganisms may be performed to rule out an infection, given the granulomatous nature of the infiltrate.
Melkersson-Rosenthal syndrome: Shows the exact same pathology but clinically also shows facial nerve palsy and a “scrotal” tongue.
Crohn disease: Oral involvement with Crohn disease will be histologically identical. Clinical correlation is needed.
Sarcoid: Sarcoidal granulomas tend to be more overt and larger but some cases can be difficult/impossible to distinguish from orofacial granulomatosis.
© 2019 DermNet New Zealand Trust.
DermNet NZ does not provide an online consultation service. If you have any concerns with your skin or its treatment, see a dermatologist for advice.