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Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2014.
Pityriasis rubra pilaris or PRP presents clinically as a papulosquamous eruption with follicular plugging and perifollicular erythema. The various clinical forms share the same histopathologic features.
In PRP, the epidermis shows regular acanthosis and psoriasiform hyperplasia (figures 1-3). The horn is thickened with parakeratotic foci between orthokeratosis both vertically and horizontally (not seen clearly in the presented images). The hyperkeratosis tracks down the openings of follicular structures forming follicular plugs (figures 1-3). The dermis may contain a mixed sparse infiltrate which may be lichenoid. Rarely, foci of acantholysis may be seen (figure 3) and some authors have made associations with Darier disease.
None are generally needed. PAS may be helpful to rule out fungal infections.
Psoriasis – Neutrophilic infiltrates and spongiform pustulation are clues to psoriasis.
Syphilis – Can be in the differential with there is a psoriasiform eruptions with lichenoid features and plasma cells.
Mycosis fungoides – Mixed psoriasiform spongiotic and lichenoid patterns raise the possibility of mycosis fungoides or parapsoriasis.
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