Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.
Pleomorphic-Hyalinising Angiectatic Tumour (PHAT) is a rare low-grade neoplasm which most commonly presents in adults as a slow-growing subcutaneous mass. As PHAT tends to be infiltrative, it is prone to local recurrence. Metastasis has never been reported.
There have been reports of PHAT recurring as overt sarcoma, but it is unclear whether these cases were misdiagnosed or whether evolution into overt sarcoma may occur.
Histology of Pleomorphic Hyalinising Angiectatic Tumour (PHAT)
Microscopically, PHAT is characterized by thin-walled, hyalinised and dilated blood vessels (figures 1, 2). Surrounding these is a stroma containing tumour cells which are plump spindled or ovoid cells with pleomorphic nuclei and occasional nuclear pseudoinclusions (Figures 2-3). Mitotic figures are rarely found. There may be extensive hemosiderin deposition (figure 3).
Myxofibrosarcoma – These exhibit numerous mitoses. There have been reports of myxofibrosarcoma with areas suggestive of PHAT. If fully sampled, it is expected that such lesions should include classic areas of myxofibrosarcoma with a high proliferative index.
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