Primary cutaneous diffuse large B cell lymphoma pathology

Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, 2010.


Within the group of cutaneous B cell lymphomas, further categorisation includes primary cutaneous diffuse large B cell lymphoma, leg type; primary cutaneous diffuse large B cell lymphoma, other; plasmablastic lymphoma and T cell rich large B cell lymphoma. The primary cutaneous B cell lymphoma leg type indicates a poor prognostic group typically seen on the lower legs of the elderly, and is illustrated in the figures below.

Histology of primary cutaneous diffuse large B cell lymphoma

Scanning power view of the histology of primary cutaneous diffuse large B cell lymphoma is of a dense superficial and deep cellular infiltrate (figure 1). Higher power identifies a dense atypical lymphocytic proliferation, which frequently extends into the subcutaneous tissue (figures 2, 3, 4, 5). Areas of crush artefact are common, and while not specific may be a clue to a malignant lymphoid population (figures 2, 3). The lymphocytes are large centroblast-like and immunoblast-like cells with non-cleaved nuclei and prominent nucleoli (figure 6, 7).

Primary cutaneous diffuse large B cell lymphoma pathology

Special stains in primary cutaneous diffuse large B cell lymphoma

Immunostaining reveals a CD20 positive B (figure 8) cell population with diffuse BCL2 (figure 9) and MUM1 staining. BCL6 expression is variable while CD10 is negative.

Primary cutaneous diffuse large B cell lymphoma – immunostaining

Differential diagnosis of primary cutaneous diffuse large B cell lymphoma

Primary cutaneous diffuse large B cell lymphoma, other, refers to those cases where the clinical features, histology and immunohistochemistry do not fit with primary cutaneous diffuse large B cell lymphoma, leg type, while also not consistent with a diagnosis of primary cutaneous follicle centre lymphoma.

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Related information

 

References:

  • Kempf W, Sander CA. Classification of cutaneous lymphomas – an update. Histopathology 2010;56:57-70.
  • Skin Pathology (2nd edition, 2002). Weedon D
  • Pathology of the Skin (3rd edition, 2005). McKee PH, J. Calonje JE, Granter SR

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