Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.
Prurigo pigmentosa is a rare dermatosis most commonly described in young Asian women. It presents as an intensely pruriticpapulareruption, which resolves with reticulatedpigmentation.
Histology of prurigo pigmentosa
In well established prurigo pigmentosa, histopathologic examination reveals a sparse lichenoidinfiltrate which also involves the superficial plexus and parakeratosis (figure 1). There are numerous dermalmelanophages in later stages (figure 2). High power examination shows the lichenoid reaction is associated with apoptotic and necrotickeratinocytes present at all levels of the epidermis (figure 3). It is quite common to find a suppurative folliculitis and often hairfollicles are filled with bacteria (figure 4).
In earlier stages of prurigo pigmentosa, there may be numerous neutrophils and eosinophils, sometimes forming abscesses in the epidermis.
The histological features of prurigo pigmentosa have been compared to those of pityriasis lichenoides.