Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.
Silver nitrate can be mistaken for melanoma clinically. It typically presents on patients who work with the agent and unwittingly spill some of the agent onto their skin.
Histology of silver nitrate pigmentation
Brown-black granules are present in the stratum corneum (figures 1, 2). The illustrated case was removed due to a dermatoscopic suspicion of melanoma. The patient was a GP who had recently used silver nitrate for a medical procedure.