Authors: Dr Achala Liyanage, Dermatology Fellow, Waikato Hospital, Hamilton, New Zealand; Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand. January 2015.
Transient acantholytic dermatosis or Grover disease generally affects elderly men, who often present with pruriticerythematouspapules, erosions and vesicles predominantly on the upper torso.
Histology of transient acantholytic dermatosis
There are four histological patterns described in transient acantholytic dermatosis. More than one histological pattern may be present.
Pemphigus vulgaris-like pattern
Microscopically, there is clefting in the upper layers secondary to acantholysis. There is usually a superficial dermalinfiltrate of lymphocytes and eosinophils are sometimes present. Eosinophilicspongiosis is common in early lesions.