What are acquired keratodermas?
Acquired keratoderma are keratodermas that are NOT inherited as a primary genetic condition. They may occur as part of a generalised skin condition (some of which may be inherited) or as a result of another illness.
How do they present?
Acquired palmoplantar keratoderma is more likely to present in adulthood (compared with inherited keratodermas which usually present in childhood). It presents with thickening of the skin of the palms and/or soles which may be diffuse (involving most of the palms and soles) or focal (localised mainly to pressure areas).
What causes acquired keratoderma?
Some of the causes of acquired keratoderma are shown in the table below.
|Inflammatory skin conditions|
|Secondary to inherited conditions that may not usually result in keratoderma|
|Medications and toxins|
Treatment of acquired keratoderma
The following treatments soften the thickened skin and make them less noticeable.
- Keratolytics (e.g. 6% salicylic acid in 70% propylene glycol)
- Topical retinoids
- Topical vitamin D ointment (calcipotriol)
- Systemic retinoids (acitretin)
On DermNet NZ:
- Palmoplantar keratoderma (introduction)
- Diffuse hereditary palmoplantar keratoderma
- Hereditary focal palmoplantar keratoderma
- Punctate keratoderma
- Cracked heels
- Keratosis Palmaris et Plantaris – Medscape Reference
Books about skin diseases:
See the DermNet NZ bookstore