Afamelanotide

Author: George Shand, Final Year Medical Student, University of Auckland, New Zealand; Chief Editor: Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand, August 2015.

What is afamelanotide?

Afamelanotide (SCENESSE®, Clinuvel Pharmaceuticals) is a potent alpha-melanocyte-stimulating hormone analogue, which stimulates the production of eumelanin in the skin. This injectable synthetic melanotropic peptide is also known as Melanotan I.

Eumelanin is a form of melanin, the tanning pigment in the skin. Production of melanin is usually stimulated by exposure to the ultraviolet (UV) radiation component of sunlight.

What skin conditions respond to afamelanotide?

Afamelanotide is registered to treat erythropoietic protoporphyria. It has been reported to be of benefit to patients with:

Erythropoietic protoporphyria

Erythropoietic protoporphyria is a rare, inherited disorder of metabolism typically manifesting in early childhood as painful photosensitivity. One to 20 minutes after sun exposure, patients experience burning pain on exposed skin, usually hands and face, followed by swelling and redness. The fear of this pain can have a major effect on quality of life including work and recreational opportunities.

Afamelanotide has been shown through Phase III studies to decrease phototoxic reactions and recovery time in patients with erythropoietic protoporphyria. Afamelanotide was first used for treatment of erythropoietic protoporphyria in Italy and Switzerland in 2007.

Solar urticaria

Solar urticaria is a rare form of chronic physical or inducible urticaria characterized by itch, weal and flare within minutes of sunlight exposure. The use of afamelanotide has been shown under experimental conditions to reduce weal formation secondary to increased melanisation.

Vitiligo

Vitiligo is a disorder characterised by white patches of skin due to selective loss of epidermal melanocytes. UVB phototherapy is a cornerstone of vitiligo management; however repigmentation has been shown to be faster and superior when phototherapy is used in conjunction with afamelanotide.

Hailey-Hailey disease

Afamelanotide was prescribed to 2 patients with Hailey-Hailey disease (benign familial pemphigus) resulting in remission.

Does afamelanotide work as a sunscreen?

The use of afamelanotide has been associated with a 50% decrease in epidermal sunburn cells, as well as a significant reduction in thymine dimer formation (part of the process by which UVB damages DNA). However, the marketers of afamelanotide do not recommend its use as a sunscreen or treatment of sunburn.

Contraindications to afamelanotide

Because no data is available, contraindications to afamelanotides include:

How to take afamelanotide

Afamelanotide (Scenesse®) comes as a white rod approximately 1.7 cm in length and 1.5 mm in diameter. It contains 16 mg of afamelanotide and is administered under the skin, usually around your hip. It should be inserted by a specialist physician every 2 months, prior to and during increased sunlight exposure (eg summer). It is recommend to have three implants per year, with a maximum of four per year.

The patient is asked to wait for 30 minutes in case of allergic reaction to it.

Tests before/after starting afamelanotide

Tests before starting afamelanotide may include:

Additional tests may be necessary for those with heart or breathing problems, diabetes, Cushing disease, Addison disease, Peutz-Jeghers syndrome, epilepsy, anaemia or skin cancer.

Regular full-body skin examinations are recommended to monitor pigmented lesions and other skin abnormalities, especially in those with a personal history of skin cancer.

Side effects of afamelanotide

Few major side effects have been reported thus far.

There is no evidence that afamelanotide increases the risk of melanoma. The primary risk factor for melanoma is UVB irradiation. Eumelanin production reduces UVB skin penetration and scavenges free radicals, hence protecting the skin.

Drug interactions with afamelanotide

Due to the method of administration, patients taking blood thinning medication may experience bruising or bleeding at the site of implantation.

No specific drug interactions have been identified to date (2015).

Safety measures

Related information

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