Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.
Botryomycosis (bacterial pseudomycosis) is an uncommon chronic bacterial infection of skin caused by masses of colonizing bacteria. Staphylococcus aureus is the usual cause, but a wide range of gram negative organisms have also been isolated.
Histology of botryomycosis
Histopathologic examination of botryomycosis shows a marked inflammatory response, scarring and suppuration. Trans-epidermal elimination, and marked epithelial hyperplasia may also sometimes be seen (figure 1).
Botryomycosis resembles mycetoma with granules present within suppurative inflammation. The granules are composed of blue-stained bacteria surrounded by an intensely eosinophilic coat (the Splendore-Hoeppli Phenomenon, figure 2).