Author: Assoc Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.
Botryomycosis (bacterial pseudomycosis) is an uncommon chronicbacterialinfection of skin caused by masses of colonizing bacteria. Staphylococcus aureus is the usual cause, but a wide range of gram negative organisms have also been isolated.
Histology of botryomycosis
Histopathologic examination of botryomycosis shows a marked inflammatory response, scarring and suppuration. Trans-epidermal elimination, and marked epithelialhyperplasia may also sometimes be seen (figure 1).
Botryomycosis resembles mycetoma with granules present within suppurativeinflammation. The granules are composed of blue-stained bacteria surrounded by an intensely eosinophilic coat (the Splendore-Hoeppli Phenomenon, figure 2).