Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, December 2016.
Cutaneousplasmacytoma is a rare (< 1%) manifestation of multiple myeloma or plasma cell leukaemia. It disproportionately affects IgA and IgD proliferations and is associated with a worsened prognosis.
Histology of plasmacytoma
There is a dense cellular infiltrate (Figure1) filling the biopsy specimen. This is comprised of a monotonous population of plasma cells (figure 2).
There are histologic grading criteria described by Bartl et al in 1987. Cases can be classified as well differentiated (grade I), moderately differentiated (grade II), or poorly differentiated (grade III) based on plasma cell morphology.
The plasma cells show a monoclonal profile confirmed by increased kappa or lambda staining on immunohistochemistry (figures 3, 4) or FISH. Plasma cells are also highlighted by CD138 immunostaining (figure 5).
Pathology of the Skin (3rd edition, 2005). McKee PH, J. Calonje JE, Granter SR
Bartl RFB, Fateh-Moghadam A, Kettner G, Jaeger K, Sommerfeld W: Histologic classification and staging of multiple myeloma: a retrospective and prospective study of 674 cases. Am J Clin Pathol. 1987, 87: 342-355. PubMed.