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Strongyloidiasis

Author: Vanessa Ngan, Staff Writer, 2008.

What is strongyloidiasis?

Strongyloidiasis is an intestinal infection caused by the parasitic roundworm (nematode) Strongyloides stercoralis. It differs from other parasitic nematode infections, e.g. filariasis, in both its clinical characteristics and its complex life cycle.

Where is strongyloidiasis found?

Strongyloidiasis is predominantly a disease of tropical and sub-tropical countries, but cases also occur in temperate climates (including southeastern states of the United States). In countries such as West Africa, Southeast Asia and the Caribbean, infection rates are as high as 40%. It is most frequently found in rural areas, institutionalised-care settings, and in lower socio-economic groups. It is estimated to affect the lives of 70 million people worldwide.

The strongyloides life cycle

The most common way of contracting strongyloidiasis is penetration of the strongyloides larvae through skin during contact with contaminated soil.

The larvae travel via the bloodstream to the lungs or directly to the small intestine. Infection via the lungs eventually reaches the pharynx (back of the mouth), where the larvae are swallowed, and reach the small intestine. Once in the small intestine they moult twice to become parasitic adult female worms.

The adult worms live entwined in the lining of the small intestine and produce eggs that yield noninfective (rhabditiform) larvae. These larvae can be passed out of the host’s body in the stools where they moult, mate, and multiply through the free-living life cycle.

Alternatively, under certain conditions, autoinfection can occur. This is where the larvae become infective, carry out their life cycle and reinfect the body without even leaving the host.

What are the signs and symptoms of strongyloidiasis?

There are several clinical forms of strongyloidiasis.

Uncomplicated strongyloidiasis

In the acute phase directly after infection patients may get a mild itchy rash that often occurs at the site of larval skin penetration, usually on the feet. This may spread to the buttocks and waist areas. This rash has been referred to as ground itch. Gastrointestinal symptoms may include diarrhoea, abdominal pain and occasionally nausea and vomiting. Patients may also have a low-grade fever, coughing and wheezing, due to the migration of larvae through the lungs.

Strongyloidiasis can become chronic from persistent infection. Many patients with chronic disease become completely asymptomatic. Periodically they may experience vague abdominal discomfort, intermittent diarrhoea and constipation, and recurrent rashes.

Recurrent rashes are known as larva currens or creeping infection. It occurs from strongyloides autoinfection and appears as an eruption beginning in the perianal region that rapidly spreads and causes intense itching. Episodes usually last several hours before subsiding again for weeks or months. Because of autoinfection recurrent larva currens may continue for many years, often decades.

Persistent strongyloidiasis infection can mimic peptic ulcer and gall bladder disease and often patients undergo treatment or surgery for either or both, only to fail to respond to these therapies.

Severe strongyloidiasis

There are 2 severe forms of strongyloidiasis, hyperinfection syndrome and disseminated strongyloidiasis.

Clinical signs and symptoms of severe strongyloidiasis can occur suddenly and involves severe abdominal pain, nausea and vomiting, bloody diarrhoea, coughing up blood, shortness of breath, stiff neck, headache, confusion, fever, chills and skin rash.

Skin rash may appear as petechiae and purpura over the trunk and extremities. The massive migration of larvae within the skin causes small blood vessels under the skin to break and bleed out.

How do you treat strongyloidiasis?

Treatment of strongyloidiasis is with anthelminthic therapy. Ivermectin is the drug of choice for uncomplicated strongyloidiasis. This drug does not kill the larvae form only the adult worms so repeat dosing is necessary to completely eradicate the infection. Other drugs that are effective include albendazole and thiabendazole.

In addition to anthelmintic therapy for severe forms of strongyloidiasis, supportive therapy such as intravenous fluids for volume depletion, blood transfusion for GI bleeding, and mechanical ventilation for respiratory failure, may be required. Antibiotic therapy may be indicated if bacteremia or meningitis has also developed.

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