Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, 2012.
Trichilemmal cyst is also known as pilar cyst. It is seen on the scalp and multiple cysts are common.
Histology of trichilemmal cyst
Scanning power view of trichilemmal cyst shows a epithelial lined cyst filled with brightly eosinophilic keratinaceous debris (Figure 1). Focal rupture of the cyst may occur with an associated giant cell reaction (Figure 2). Closer inspection of the cyst wall identifies trichilemmal differentiation (Figures 3 and 4) as occurs in the outer root sheath of the hair follicle. This is seen as maturation of squamousepithelium with lack of a granular layer. The eosinophilickeratin centrally is densely packed frequently displaying cholesterol clefts. Focalcalcification is seen in around 25% of cases (Figure 5).
Proliferating trichilemmal cyst: In this variant squamousproliferation can be seen arising from the cyst wall.
Malignantproliferating trichilemmal tumour: This tumour arises out of a pre-existing trichilemmal cyst. Clear transition is evident into an area of eccentric asymmetrical growth with malignant cytology
Epidermal inclusion cyst: This cyst retains a granular layer within the maturing epithelialcyst wall.
Vellus haircyst: The cyst contents contain multiple vellus hairs seen as small non pigmented hair shafts.
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