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Clofazimine

Author: Vanessa Ngan, Staff Writer, 2003.

Clofazimine is a drug used to treat leprosy. It can slow down the growth and weakly kill Mycobacterium leprae, the bacteria that cause leprosy. It is used in combination with rifampicin and dapsone for the treatment of the many forms of leprosy. In particular, it is used to treat erythema nodosum leprosum, the red lumps and thickened patches often seen in lepromatous leprosy.

Because of its antiinflammatory effects, clofazimine is also sometimes used as a second or third line therapy for various skin conditions including:

Clofazimine is available as a 50mg capsule. The trade name in New Zealand is Lamprene®.

How to use clofazimine

For the treatment of leprosy, clofazimine should always been given in combination with other specific antibiotics. Multidrug therapy is necessary to prevent the development of drug resistance.

To ensure maximum absorption clofazimine should be taken with food or with milk.

Precautions

Clofazimine should be not be used in the following patients. If clofazimine treatment is unavoidable, these patients should be monitored closely.

If patients develop gastrointestinal symptoms such as diarrhoea or vomiting during treatment, the dosage should be reduced or the medication taken less often. Failure to do this may result in accumulation of clofazimine in tissues that can lead to blockage of the intestines.

Clofazimine may be used in pregnant women with leprosy if the potential benefits justify the risk to the fetus. The World Health Organisation recommends that clofazimine be continued during pregnancy, as the symptoms of leprosy appear to worsen over this time. Clofazimine crosses the placenta, and skin discolouration has been seen in neonates.

Clofazimine also passes into breast milk resulting in skin discolouration in the infant.

Side effects

Side effects that occur frequently (>10%) include:

Side effects that occur rarely include:

New Zealand approved datasheets are the official source of information for these prescription medicines, including approved uses and risk information. Check the individual New Zealand datasheet on the Medsafe website.

Related information

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