Contact reactions to lipsticks and other lipcare products

Author: Dr Delwyn Dyall-Smith FACD, Dermatologist, 2010.


Lipsticks and other lipcare products such as lipliners, lip balms/salves, lip gloss, lip plumpers and sunscreens can cause:

Cheilitis is the medical term for inflamed lips.

A basic lipstick is composed of the stick, emollient, solvent for the dyes, preservatives/anti-oxidants, perfumes/flavourings and colours. Further chemical agents may be added for gloss, water-resistance, sealant, cushioning, texture and richness.

Allergic contact cheilitis due to lip cosmetics

Who gets allergic contact cheilitis due to lip cosmetics?

Lipsticks and lipcare products are the commonest cause of allergic contact cheilitis in women. And as the majority of patients presenting with cheilitis are women, this makes these products the most common overall source of allergens. Toy make-up may contain high levels of fragrances and metals, above those recommended for cosmetics, and may play a role in sensitization. Lipsticks are regarded as moderate-risk cosmetics for the development of allergic reactions.

Clinical presentation

Lipsticks and other lip care products are the major causes of allergic cheilitis of the vermilion margin, where the skin and red lip meet. Sometimes the reaction extends onto adjacent perioral skin, with or without involvement of the angles of the mouth.

The reaction may present in either acute or more persistent chronic forms.

Acute allergic contact cheilitis may mimic contact urticaria, with swelling and small blisters within minutes of contact with the allergen. The reaction may spread to the face and neck.

The chronic form, however, presents with redness, scaling or dryness, and itch. There may be associated mild swelling. Typically it begins within hours of contact and may persist for days, weeks or months if exposure to the allergen continues.

Pigmented allergic contact cheilitis has also been reported due to lipsticks.

How is allergic cheilitis to lip cosmetics diagnosed?

Patch testing is the investigation for contact allergy due to Type IV (delayed) hypersensitivity. Patch testing should include the standard series and an extended series such as perfumes/flavourings and other components found in lipcare products. It is important to also test the patient's own products as in a significant number of cases the patient only reacts to these.

Many cosmetic companies are willing to co-operate with dermatologists to find the specific allergen in their product. They will usually supply de-identified samples which can be used for patch testing, and will then identify the chemical that gives a positive patch test. This means the patient knows what to avoid in future and provides the cosmetic company with feedback about a possible problem with their product. It is not uncommon for a patient to react to more than one allergen in lipcare products.

Treatment

Avoidance of the allergen usually results in resolution of the inflammation. Sometimes however there is more than one contributing factor to the cheilitis and it is therefore important to be re-assessed if the cheilitis persists despite not using the identified product.

Allergens reported in lipcare products

Eosin, or a contaminant of it, was the commonest allergen identified in lipsticks up until 1960. Since then eosin has been used less often in lipstick formulations and is also more highly purified, so is rarely a problem now.

Ricinoleic acid, the main constituent of castor oil, has been identified in several large case series as the commonest current cause of allergic cheilitis due to lip cosmetics.

Some other allergens identified in lipsticks and lipcare products as causing allergic cheilitis reactions:

  • Nickel – from the metal casing
  • Perfumes and flavourings – fragrance mix; Myroxylon pereirae (balsam of Peru); citral; cinnamaldehyde; peppermint oil; vanilla; geraniol;
  • Emollients – lanolin; castor oil; olive oil; almond oil; coconut oil; branched chain fatty acid esters such as glyceryl diisostearate, diisostearyl malate, glyceryl monoisostearate monomyristate; propylene glycol; oleyl alcohol; 12-hydroxystearic acid (major fatty acid in hydrogenated castor oil); isopalmityl diglyceryl sebacate (DGS) – was synthesised as a replacement for castor oil in Japan and exported to other Asian countries, but not to Europe. It is already being withdrawn from lipsticks and lip gloss.
  • Solvent for dyes – castor oil
  • Colours – D&C Yellow #11; D&C Red #7, 17, 21 (eosin), 36; Lithol Rubine BCA; quinazoline yellow
  • Preservatives/anti-oxidants – propyl gallate
  • Additional components:
  • Sunscreens – benzophenone-3
  • Gloss – colophonium and its derivative ester gum (main allergen believed to be glyceryl-1-mono abietate); propolis (and other propolis-related substances including cera alba, propolis cerus, beeswax acid, synthetic beeswax) is also used as an emulsifier and thickening agent in cosmetics
  • Water-resistant film – polyvinylpyrrolidone / hexadecene copolymer (also used to improve stick integrity, give a rich feel and disperse the pigment)
  • ‘Anti-irritant agent’ – bisabolol (main active ingredient in chamomile)
  • Sealant – shellac
  • Cushioning/texture – di-isostearyl malate (fatty ester)
  • Vitamin E

Irritant contact cheilitis due to lip cosmetics

Irritant contact cheilitis is a diagnosis of exclusion, made when investigations for an allergic cause have been negative, the patient is not atopic and lip-licking (perlèche) has not been observed. Manufacturers avoid well known irritants, but mild irritants may still be present.

Some components of lipcare products can be both irritant and allergenic. Examples of such irritants include: olive oil, citral, shellac and cinnamon.

As with allergic contact cheilitis, there should be an improvement when the source of irritation is avoided. Lip licking in response to the dryness, may however continue an irritant dermatitis despite avoiding the original irritant.

Contact urticaria due to lip plumpers

Lip plumpers are cosmetics used to increase the apparent volume of the lips either by vasodilation or hydration. Vasodilation may be achieved by one of three mechanisms:

  • Nonimmunological contact urticaria – is the most frequent immediate contact reaction and is due to cinnamon and cayenne pepper affecting prostaglandin metabolism. It may resemble irritant contact cheilitis clinically.
  • Irritant contact cheilitis – is the most common reaction to spices such as cinnamon and cayenne pepper which act on receptors that release substance P.
  • Direct vasodilation effect – benzyl nicotinate, L-arginine.

Lip swelling is the desired effect following use of lip plumper. However a kiss soon after application of the product may result in an unintended transfer of the reaction.

 

Related Information

References:

  • Asai M, Kawada A, Aragane Y, Tezuka T. Allergic contact cheilitis due to glyceryl monoisostearate monomyristate in a lipstick. Contact Dermatitis 2001; 45: 173.
  • Beukers SM, Rustemeyer T, Bruynzeel DP. Cheilitis due to olive oil. Contact Dermatitis 2008; 59: 253–255.
  • Bonamonte D, Foti C, Angelini G. Contact allergy to ester gums in cosmetics. Contact Dermatitis 2001; 45: 110–111.
  • Firoz EF, Levin JM, Hartman RD, James WD. Lip plumper contact urticaria. J Am Acad Dermatol 2009;60:861-863.
  • Guin JD. Allergic contact cheilitis from di-isostearyl malate in lipstick. Contact Dermatitis 2001; 44: 375.
  • Hindle E, Ashworth J, Beck HM. Cheilitis from contact allergy to citral in lip salve. Contact Dermatitis 2007; 57: 125–126.
  • Ichihashi K, Soga F, Katoh N, Kishimoto S. Allergic contact cheilitis from pentaerythritol rosinate in a lipstick. Contact Dermatitis 2003; 49: 213.
  • Ido T, Nishikawa M, Kiyohara T, Ishiguro K, Kumakiri M. Pigmented contact cheilitis from dipentaerythritol fatty acid ester. Contact Dermatitis 2008; 59: 117–118.
  • Inui S, Azukizawa H, Katayama I. Recurrent contact cheilitis because of glyceryl isostearare, diisostearyl maleate, oleyl alcohol and Lithol Rubine BCA in lipsticks. Contact Dermatitis 2009; 60: 231-232.
  • Jacob SE, Chimento S, Castanedo-Tardan MP. Allergic contact dermatitis to propolis and carnauba wax from lip balm and chewable vitamins in a chld. Contact Dermatitis 2008; 58: 242-243.
  • Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006; 55: 312-313.
  • Leow Y-H, Tan S-H, Ng S-K. Pigmented contact cheilitis from ricinoleic acid in lipsticks. Contact Dermatitis 2003; 49: 48-49.
  • Lim SW, Goh CL. Epidemiology of eczematous cheilitis at a tertiary dermatological referral centre in Singapore. Contact Dermatitis 2000; 43: 322–326.
  • Orton DI, Salim A, Shaw S. Allergic contact cheilitis due to shellac. Contact Dermatitis 2001; 44: 250.
  • Özkaya E, Topkarcı Z, Özarmagä̆n G. Allergic contact cheilitis from a lipstick misdiagnosed as herpes labialis: Subsequent worsening due to Zovirax® contact allergy. Australas J Dermatol 2007; 48: 190–192.
  • Pastor N, Silvestre JF, Mataix J, Lucas A, Pe ́rez M. Contact cheilitis from bisabolol and polyvinylpyrrolidone/hexadecene copolymer in lipstick. Contact Dermatitis 2008; 58: 178–179.
  • Quartier S, Garmyn M, Becart S, Goossens A. Allergic contact dermatitis to copolymers in cosmetics – case report and review of the literature. Contact Dermatitis 2006; 55: 257–267.
  • Schram SE, Glesne LA, Warshaw EM. Allergic contact cheilitis from benzophenone-3 in lip balm and fragrance/flavorings. Dermatitis 2007; 18: 221-224.
  • Sowa J, Suzuki K, Tsuruta K, Akamatsu H, Matsunaga K. Allergic contact dermatitis from propylene glycolricinoleate in a lipstick. Contact Dermatitis 2003; 48: 228–229.
  • Sugiura M, Hayakawa R, Sugiura K. Contact dermatitis due to lipsticks and a cream containing isopalmityl diglyceryl sebacate (DGS). Contact Dermatitis 2006; 54: 213–214. Tran A, Pratt M, DeKoven J. Acute allergic contact dermatitis of the lips from peppermint oil in a lip balm. Dermatitis 2010; 21: 111-115.

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