Epidermal naevus pathology

Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, 2010.

Epidermal naevus falls into the category of benign epidermal tumours.

Histology of epidermal naevus

The scanning power view of epidermal naevus is of an epidermal proliferative process (Figure 1). Low power reveals hyperkeratosis and papillomatosis across the breadth of the specimen (Figures 2 and 3). Epidermal hyperplasia forms finger like projections with the intervening invaginations filled with hyperkeratotic material (Figure 4). Frequently incidental fungal spore forms are seen. Extending below the projections into the dermis are anastamosing thickened cords of acanthotic epidermis (Figure 5). Dermal collagen and telangiectatic vessels can be seen within the papillary projections (Figures 5 and 6).

A variable inflammatory infiltrate may accompany the epidermal changes, more prominent in the inflammatory verrucous variant.

Epidermal naevus pathology

Histological variants of epidermal naevus

A number of reported variants exist including acantholytic, porokeratotic, acanthosis nigricans like, Hailey-Hailey disease-like and verrucous.

Differential diagnosis of epidermal naevus

Inflammatory Verrucous Epidermal Naevus (ILVEN): This naevus is likely simply a subtype of the epidermal naevus. In addition to the superficial perivascular or lichenoid lymphocytic infiltrate specific epidermal changes are recognised. Areas of alternating parakeratosis and orthokeratosis are seen. Beneath the parakeratosis there is hypogranulosis, whereas beneath the orthokeratosis there is hypergranulosis.

Seborrhoeic keratosis: While clinical correlation is essential here, the presence of elongated down-growths of epidermis with some flattening at the base is more in keeping with an epidermal nevus.

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Related information



  • Skin Pathology (2nd edition, 2002). Weedon D
  • Pathology of the Skin (3rd edition, 2005). McKee PH, J. Calonje JE, Granter SR

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