Author: Vanessa Ngan, Staff Writer, 2002. Updated by Hon A/Prof Amanda Oakley, September 2015.
Roseola is a disease caused by human herpes virus type 6B (HHV-6B) and possibly type 7 (HHV-7). These herpes viruses have only been identified in recent years and we are still learning about the full range of diseases caused by them.
Roseola is characterised by high fever lasting for 3–5 days, runny nose, irritability and tiredness. As the fever subsides a rash (exanthem) may appear on the face and body.
Roseola is also known by the names roseola infantum and exanthem subitum.
Roseola is most commonly seen in children between 6 months and 3 years of age. Most children (86%) will have had roseola by the age of 1 year. Roseola is rarely seen in adults, as infection during childhood probably confers lifelong immunity to the disease. Repeat attacks have been known to occur but are not common.
Roseola is spread from person to person via saliva of asymptomatic family members. The incubation period for roseola is approximately 9–10 days after exposure.
In many cases of roseola, the child appears well with few or no signs or symptoms. Typical cases are characterised by the following:
In some cases, a child may be infected with the virus and never develop the rash. Less commonly, the rash may appear without a preceding fever. In most cases, particularly if fever is low, the child is well. In about 5–15% of young children, high fevers may trigger febrile seizures.
Because roseola is usually mild and self-limiting, diagnosis is usually solely based on the characteristic history and physical examination.
Some laboratories can confirm HHV-6 infection by serology or polymerase chain reaction (PCR).
There is no specific treatment for roseola. The disease is usually mild and self-limiting. Rest, maintaining fluid intake and paracetamol for fever is all that is usually required. No treatment is necessary for the rash, as it does not itch or hurt and fades spontaneously.
Complications are rare with roseola in most children. The most common complication is febrile seizures/convulsions that may occur in 5–15% of children. These are triggered by the high fevers of roseola and may be alarming when seen for the first time. Signs of a febrile seizure include:
These seizures are brief and not dangerous. However, you should have your child examined by a doctor if one happens.
Acute encephalitis, heptatis, myocarditis, haemophagocytic syndrome and infectious mononucleosis-like illness occur only very rarely.
Reactivation of HHV-6 in immune suppressed patients or in association with drug hypersensitivity syndrome results in fever, rash, pneumonia, hepatitis, bone marrow suppression and encephalitis.
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