Subcutaneous fat necrosis of the newborn

Author: Dr Diana Purvis, Dermatology Fellow, Green Lane Hospital, Auckland


What is subcutaneous fat necrosis of the newborn?

Subcutaneous fat necrosis of the newborn is a rare condition resulting in firm, inflamed, skin-coloured to purple nodules (lumps) in the fat, It occurs in the first weeks after birth. It is a form of panniculitis.

The nodules may present as discrete lumps on the back, buttocks and limbs, or as large hardened areas. It is less severe than sclerema neonatorum, another condition that may cause hardened skin in a newborn baby.

Subcutaneous fat necrosis of the newborn

What causes it?

The exact cause of subcutaneous fat necrosis is not known. A number of factors seem to be more common in affected infants including:

  • Fetal stress during delivery
  • Low oxygen levels
  • Cold temperature
  • Caesarian section
  • Large birth weight
  • Infection

However most babies who are exposed to these factors do not get subcutaneous fat necrosis.

What are the complications?

The nodules of subcutaneous fat necrosis may be painful. They may last from weeks to months before they disappear. Occasionally the infant may be left with a dimpled area of reduced fat.

The most common complication of subcutaneous fat necrosis is hypercalcaemia (high blood calcium). This is detected on a blood test, so babies with subcutaneous fat necrosis should have their blood calcium checked periodically for the first few months of life. Hypercalcaemia can cause irritability, constipation, poor weight gain and, very rarely, heart rhythm disturbance.

Thrombocytopenia (low platelets) and hyperlipidaemia (raised levels of fat in the blood) have also been observed.

How is it treated?

Treatment of subcutaneous fat necrosis focusses on management of hypercalcaemia, if it occurs. Hypercalcaemia may be treated by increased fluid intake, low calcium milk feeds, frusemide, corticosteroids and bisphosphonates.

The inflammation of the fat often settles without specific treatment.

 

Related Information

References:

  • Subcutaneous fat necrosis of the newborn: a systematic evaluation of risk factors, clinical manifestations, complications and outcome of 16 children. E Mahé, N. Girszyn, S. Hadj-Rabia, C. Bodemer, D. Hamel-Teillac and Y. De Prost. British Journal of Dermatology 2007 156,pp709-715
  • Subcutaneous fat necrosis of the newborn: a review of 11 cases. AD Burden, BR Krafchik. Pediatric Dermatology 1999 16(5),384-387

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