Topical retinoids are creams, lotions and gels containing medicine derived from Vitamin A. These compounds result in proliferation and reduced keratinisation of skin cells independent of their functions as a vitamin.
Many brand-name creams containing the retinoids retinol and retinaldehyde can be obtained over the counter at pharmacies and supermarkets.
The more potent topical retinoids available on prescription are:
Adapalene gel has received approval from the FDA in the USA for over-the-counter use of acne treatment in patients 12 or older (July 2016). It is also available to treat acne in combination with benzoyl peroxide.
Tretinoin, isotretinoin and adapalene are used for:
Topical retinoids can irritate the skin, especially when first used in people with sensitive skin, resulting in stinging. Excessive use results in redness, swelling, peeling and blistering in treated areas. It may cause or aggravate eczema, particularly atopic dermatitis.
By peeling off the top layer of skin, they may increase the chance of sunburn. Irritation may also be aggravated by exposure to wind or cold, use of soaps and cleansers, astringents, peeling agents and certain cosmetics.
Some people have reported a flare of acne in the first few weeks of treatment, which usually settles with continued use.
Retinoids taken by mouth may cause birth deformities. Manufacturers recommend that topical retinoids are not used in pregnancy or breastfeeding as negative animal studies are not always predictive of human response.
Follow these instructions carefully.
Tan J, Tanghetti E, Baldwin H, Stein Gold L, Lain E. The Role of Topical Retinoids in Prevention and Treatment of Atrophic Acne Scarring: Understanding the Importance of Early Effective Treatment. J Drugs Dermatol. 2019 Mar 1;18(3):255-260. PubMed PMID: 30909329. Journal.
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