Perniosis pathology

Author: Harriet Cheng BHB, MBChB, Dermatology Unit, Waikato Hospital; A/Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.


Perniosis or chillblains are a localised form of vasculitis presenting with reddish purple bumps in reaction to cold exposure. Blistering and ulceration may occur.

Histology of perniosis

In perniosis, sections show acral skin with a dense superficial and deep lymphocytic infiltrate (figure 1). Subepidermal oedema may be marked. The characteristic feature is lymphocytic perivascular infiltrate within the dermis and sometimes extending to the subcutis (figures 2, 3). This is thought by some authors to represent the one true “lymphocytic vasculitis”, as there may be well established fibrinoid change and thrombosis can occur. There may be numerous eosinophils in early lesions (figure 4).

Perniosis pathology

Differential diagnosis of perniosis

Chillblain lupus erythematosus: Frank lymphocytic vasculitis and interface changes are more common in chillblain lupus than in idiopathic chilblains (figure 5). A positive antinuclear antibody test favours chilblain lupus erythematosus.

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Related information

 

References:

  • Dermatology (Third edition, 2012). Bolognia JL, Jorizzo JL, Schaffer JV
  • Weedon’s Skin Pathology (Third edition, 2010). David Weedon
  • Pathology of the Skin (Fourth edition, 2012). McKee PH, J. Calonje JE, Granter SR

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