Author: Harriet Cheng BHB, MBChB, Dermatology Unit, Waikato Hospital; A/Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013.
Perniosis or chillblains are a localised form of vasculitis presenting with reddish purple bumps in reaction to cold exposure. Blistering and ulceration may occur.
Histology of perniosis
In perniosis, sections show acral skin with a dense superficial and deep lymphocyticinfiltrate (figure 1). Subepidermal oedema may be marked. The characteristic feature is lymphocyticperivascularinfiltrate within the dermis and sometimes extending to the subcutis (figures 2, 3). This is thought by some authors to represent the one true “lymphocyticvasculitis”, as there may be well established fibrinoid change and thrombosis can occur. There may be numerous eosinophils in early lesions (figure 4).
Chillblain lupus erythematosus: Frank lymphocyticvasculitis and interface changes are more common in chillblain lupus than in idiopathic chilblains (figure 5). A positive antinuclear antibody test favours chilblain lupus erythematosus.