Skin signs and systemic disease

The skin may reflect signs of systemic diseases, useful for diagnosis, or suffer from a complication of disease or its treatment. Here are links to pages about the dermatological manifestations of non-infectious internal diseases: immune, autoimmune diseases and rheumatic diseases; genetic, metabolic, endocrine and nutritional states; internal malignancy; haematological diseases; psychiatric states; and drug eruptions.

• Acrodermatitis enteropathica
• Acrodynia
• Acute febrile neutrophilic dermatosis
• Amyloidosis
• Angioedema
• Annular erythema
• Antiphospholipid syndrome
• Argyria
• Autoimmune disease
• Autoinflammatory syndromes
• Behçet disease
• Biotin–responsive dermatoses
• Blau syndrome
• Bloom syndrome
• Bowel bypass syndrome
• Calciphylaxis
• Carotenaemia
• Chilblains
• Chloracne
• Churg–Strauss syndrome
• CINCA
• Compulsive skin picking
• Congenital adrenal hyperplasia
• Congenital erythropoeitic porphyria
• Connective tissue diseases
• Cornelia de Lange syndrome
• Costello syndrome
• Crohn disease
• Cronkhite–Canada syndrome
• Crouzon syndrome
• Cryoglobulinaemia
• Cushing syndrome
• Cutaneous markers of malignancy
• Cryopyrin-associated periodic syndromes
• Degos disease
• Dermatitis herpetiformis
• Dermatomyositis
• Diabetes
• Diabetic foot ulcers
• Down syndrome
• Drug eruptions
• Dysmorphophobia
• Ehler–Danlos syndrome
• Eosinophilic fasciitis
• Epstein–Barr virus-associated lymphoproliferative disorders
• Erythema multiforme
• Erythema nodosum
• Erythropoeitic protoporphyria
• Familial cold autoinflammatory syndrome
• Familial Mediterranean fever
• Flushing
• Focal dermal hypoplasia
• Genital Crohn disease
• Glucagonoma
• Gluten enteropathy in patients with dermatitis herpetiformis
• Goltz syndrome
• Gorlin syndrome
• Gout
• Graft versus host disease
• Granuloma annulare
• Haematological disease
• Haemochromatosis
• Helicobacter pylori infection
• Histiocytic necrotising lymphadenitis
• Histiocytoses
• Hodgkin lymphoma
• Hypereosinophilic syndrome
• Hyperimmunoglobulinaemia D with periodic fever syndrome
• Hypogonadism in females
• Hypogonadism in males
• IgG4 disease
• Incontinentia pigmenti
• Iron deficiency
• Itch
• Job syndrome
• Juvenile systemic granulomatosis
• Kava dermopathy
• Kwashiorkor
• LEOPARD syndrome
• Lepra reactions in leprosy
• Livedo reticularis
• Lupus erythematosus
• Lyme disease
• Majeed syndrome
• Marfan syndrome
• Mastocytosis
• McCune–Albright syndrome
• Menopause
• Metabolic syndrome
• Mevalonic aciduria
• Monogenic autoinflammatory syndromes
• Morphoea
• Mucinoses
• Muckle–Wells syndrome
• Myxoma syndrome
• Necrobiosis lipoidica
• Necrolytic migratory erythema
• Neurotic excoriations
• NOMID
• Orofacial Crohn disease
• Orofacialdigital syndrome type 1
• Orofacial manifestations of inflammatory bowel disease
• Panniculitis
• PAPA syndrome
• Periodic fever syndromes
• PFAPA syndrome
• Phaeochromocytoma
• Photosensitivity
• POEMS syndrome
• Polyarteritis nodosa
• Polymorphous eruption of pregnancy
• Porphyria cutanea tarda
• Pretibial myxoedema
• Primary cutaneous marginal-zone lymphoma
• Prolidase deficiency
• Prurigo nodularis
• Proteus syndrome
• Pruritus
• Pseudoxanthoma elasticum
• Pyoderma gangrenosum
• Pyodermatitis–Pyostomatitis vegetans
• Reiter syndrome
• Reticular erythematous mucinosis
• Rheumatoid arthritis
• Rothmund–Thomson syndrome
• SAPHO syndrome
• Sarcoidosis
• Schnitzler syndrome
• Scleroderma (localised)
• Scleredema
• Scleromyxoedema
• Scurvy
• Sézary syndrome
• Sjögren syndrome
• Skin cancer in transplant recipients
• Skin signs of gastrointestinal disease
• Skin signs of neurological diseases
• Skin signs of rheumatic disease
• Stoma skin problems
• Sweet disease
• Systemic sclerosis
• Telogen effluvium
• Thyroid disease
• Toxic epidermal necrolysis
• Tuberous sclerosis
• Tumour necrosis factor receptor-associated periodic syndrome
• Turner syndrome
• Urticaria
• Variegate porphyria
• Vasculitis
• Vogt-Koyanagi-Harada syndrome
• Waldenström macroglobulinaema
• Granulomatosis with polyangiitis
• Wells syndrome
• Whipple disease
• Wilson disease
• Xanthomas
• Xeroderma pigmentosum