Childhood melanoma

Author: Natasha Gattey, M.D. Candidate, Class of 2016 College of Medicine, University of Saskatchewan, Canada.Chief Editor: Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand, December 2014.


What is childhood melanoma?

Melanoma is a skin cancer that arises from melanocytes (pigment-producing cells). Childhood melanoma usually refers to melanoma diagnosed in individuals under the age of 18 years. It is rare.

For more information about melanoma, see:

What types of melanoma arise in childhood?

Melanoma arising in children has been classified into the following types [3]:

Childhood melanoma

What are the clinical features of childhood melanoma?

Specific kinds of melanoma are described in detail elsewhere on DermNet NZ: see melanoma resources. Some features notable in childhood melanoma are discussed here.

Melanoma in children aged 11 and older

Melanoma in older children appears similar to melanoma in adults; it presents as a growing lesion that looks different from the child's other lesions. Most are pigmented. About 60% have the ABCDE criteria:

A: Asymmetry
B: Border irregularity
C: Colour variation
D: Diameter >6 mm
E: Evolving

 

Melanoma in children aged 10 or younger

Superficial spreading melanoma is less common in younger children and melanoma has the ABCDE criteria in 40% of cases.

Melanoma in young children is more commonly amelanotic (red coloured), nodular, and tends to be thicker at diagnosis than in older children and adults.

Cordoro et al (2013) have suggested adding additional ABCD detection criteria for skin lesions in children [1]:

A: Amelanotic (the lesion is skin coloured or red)
B: Bleeding, Bump
C: Colour uniformity
D: De novo, any Diameter

 

Melanoma in congenital melanocytic naevus

Small congenital naevi arise in 1 in 100 births. Melanoma is a rare complication of small to medium congenital naevi. It tends to appear on the edge of the birthmark and is recognised by change within the mole and the ABCDE criteria described above.

The risk of melanoma is higher in larger congenital naevi [7,8]. Melanoma arises in about 4% of children 10 years or younger that have a giant congenital melanocytic naevus >40 cm in diameter. Giant congenital melanocytic naevi are very rare, arising in 1 in 20,000 births. In giant congenital melanocytic naevi:

  • Melanoma may arise within the centre of the melanoma
  • It tends to arise within deeper dermal naevus cells rather than within superficial naevus cells
  • The melanoma may also arise within the central nervous system due to neurocutaneous melanocytosis
  • The risk of melanoma is greater in giant naevi that cross the midline of the spine and in children with satellite naevi
  • Prophylactic removal of the naevi does not appear to reduce the risk of melanoma

These melanomas can be difficult to detect early. Excision may also be difficult or impossible.

Differential diagnosis of childhood melanoma

Common moles are usually easy to recognise and are uniform in structure and colour. They remain fairly stable once they have reached their final size.

Red skin nodules that can be confused with melanoma in children include Spitz naevus and pyogenic granuloma. Both of these look different from the child's other skin spots and tend to progressively enlarge. Pyogenic granuloma is prone to bleed easily. Benign proliferative nodules can arise within congenital naevi.

Who gets childhood melanoma?

Cutaneous melanoma in children is rare, and extremely rare before puberty [4]. It comprises of 3% of all pediatric cancers [2]. However, in New Zealand, melanoma is the second most common cancer registration in people aged 0–24 years [7].

Risk factors for childhood melanoma include: [4,5].

Like the adult population, melanoma mainly affects Caucasian children and is associated with sun exposure. There is a slight female preponderance [4,6].

What is the treatment for childhood melanoma?

Treatment of childhood melanoma is the same as in adults. In New Zealand:

  • Lesions that are suspicious for melanoma are completely removed by initial diagnostic excision biopsy, usually with a 2-mm clinical margin.
  • If melanoma is confirmed, a second surgical procedure is undertaken to remove a wider margin of normal skin. This is called wide local excision. The size of the margin depends on the Breslow thickness of the melanoma.
  • If the melanoma has thickness >1 mm or other features of concern, sentinel node biopsy may be offered. However its role in the paediatric population is not well established.
  • Follow-up is arranged to look for recurrence and new lesions of concern. [6]

Metastatic melanoma or advanced melanoma is melanoma that has spread to lymph nodes or elsewhere in the body. Treatment is individualised but may include surgery, radiotherapy, chemotherapy or targeted therapy.

What is the outlook for patients with childhood melanoma?

Prognosis of melanoma depends on the stage of melanoma, ie whether it has spread beyond its original site in the skin. Spread of melanoma to lymph nodes and elsewhere is more likely in thicker tumours (measured by Breslow thickness at the time of removal of the primary tumour).

Survival rates are similar in older children and adults [2,3]. However, melanomas in children under 11 years of age appear to have a less aggressive behaviour than those detected in adults [4,5].

 

Related Information

References:

  1. Cordoro KM, Gupta D, Frieden IJ, McCalmont T, Kashani-Sabet M. Pediatric melanoma: results of a large cohort study and proposal for modified ABCD detection criteria for children. J Am Acad Dermatol. 2013 Jun;68(6):913-25. doi: 10.1016/j.jaad.2012.12.953. Epub 2013 Feb 8. PubMed PMID: 23395590.
  2. Han D, Zager JS, Han G, Marzban SS, Puleo CA, Sarnaik AA, Reed D, Messina JL, Sondak VK. The unique clinical characteristics of melanoma diagnosed in children. Ann Surg Oncol. 2012 Nov;19(12):3888-95. doi: 10.1245/s10434-012-2554-5. Epub 2012 Aug 3. PubMed PMID: 22864798.
  3. Mehregan AH, Mehregan DA. Malignant melanoma in childhood. Cancer. 1993 Jun 15;71(12):4096-103. Review. PubMed PMID: 8508375.
  4. Paradela S, Fonseca E, Pita-Fernández S, Kantrow SM, Diwan AH, Herzog C, Prieto VG. Prognostic factors for melanoma in children and adolescents: a clinicopathologic, single-center study of 137 Patients. Cancer. 2010 Sep 15;116(18):4334-44. doi: 10.1002/cncr.25222. PubMed PMID: 20549825.
  5. Paradela S, Fonseca E, Prieto VG. Melanoma in children. Arch Pathol Lab Med. 2011 Mar;135(3):307-16. doi: 10.1043/2009-0503-RA.1. Review. PubMed PMID: 21366453.
  6. Rao BN, Hayes FA, Pratt CB, Fleming ID, Kumar AP, Lobe T, Dilawari R, Meyer W, Parham D, Custer MD. Malignant melanoma in children: its management and prognosis. J Pediatr Surg. 1990 Feb;25(2):198-203. PubMed PMID: 2303989.
  7. Ministry of Health. 2014. Cancer: New registrations and deaths 2011. Wellington: Ministry of Health. September 2014.
  8. Vourc'h-Jourdain M, Martin L, Barbarot S; aRED. Large congenital melanocytic nevi: therapeutic management and melanoma risk: a systematic review. J Am Acad Dermatol. 2013 Mar;68(3):493-8.e1-14. doi: 10.1016/j.jaad.2012.09.039. Epub 2012 Nov 19. Review. PubMed PMID: 23182059.
  9. Krengel S, Hauschild A, Schäfer T. Melanoma risk in congenital melanocytic naevi: a systematic review. Br J Dermatol. 2006 Jul;155(1):1-8. Review. PubMed PMID: 16792745.

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