Imiquimod

What is imiquimod?

Imiquimod is a an immune response modifier. It is manufactured as a 5% cream called Aldara™. Generic forms of imiquimod cream are also available. The Perrigo brand is funded by PHARMAC in New Zealand (2019).

A 3.75% cream called Zyclara™ has also been approved by the FDA in the USA, but is not yet available in New Zealand (March 2017).

What is imiquimod used for?

Imiquimod is mainly used to treat:

• Actinic keratoses (also called solar keratoses or AKs).
• Basal cell carcinoma (BCC), especially superficial types
• Intraepidermal carcinoma (also known as Bowen disease, or in-situ squamous cell carcinoma (SCC)), an unregistered indication at this time (June 2016)

It is also used to treat viral infections, especially genital warts. It may also be helpful in the treatment of common warts (once they have been thinned down by other means), plane warts, and herpes simplex. Experimentally it has been successful in reducing some keloid scars, granuloma annulare, vitiligo, melanoma in situ and, in combination with diphencyprone, metastatic melanoma (see topical and intralesional immunotherapy for melanoma.

Although sometimes prescribed for molluscum contagiosum, clinical trials have not shown imiquimod to be of benefit.

Before starting, a biopsy may be performed to confirm the diagnosis. Imiquimod is particularly useful on areas where surgery or other treatments may be difficult, complicated or otherwise undesirable, especially the face and lower legs. 

How does imiquimod work?

Imiquimod works by stimulating the immune system to release a number of chemicals called cytokines, which are important in fighting viruses and destroying cancer cells.

When used to treat skin cancers and pre-cancerous lesions it results in inflammation, which destroys the lesion. The degree of inflammation is quite variable from person to person, in part due to the type of skin lesion and in part due to genetic factors. The imiquimod is taken up by the so-called ‘toll-like receptor 7’ on certain immune cells that are found in the outside part of the skin (the epidermis); these receptors are expressed more in some individuals and in some skin lesions than in others.

Treatment regimes for imiquimod cream

Various imiquimod treatment regimes are used. For example:

• Actinic keratoses: imiquimod is typically used two or three times weekly for four to six weeks, repeated if necessary after a break of four weeks. Very scaly lesions should be frozen with liquid nitrogen about three weeks before starting imiquimod.
• Basal cell carcinomas and intraepidermal carcinoma: imiquimod is used five times weekly for six weeks. 
• Genital warts: imiquimod is used three times weekly; or, if available, 3.75% cream daily; until total clearance or for up to 8 weeks.

Apply the imiquimod less often if the reaction is excessive, and more often if no reaction occurs. Check with your doctor; he or she may recommend a different regime in your case. Treatment is sometimes continued for up to 16 weeks.

Treatment should be carefully monitored, because the cream may need to be applied more or less frequently than originally planned or for a shorter or longer course, depending on response. Once the inflammation has settled there is generally a good or excellent cosmetic result with little scarring. 

How to use imiquimod cream

Wash your hands before and after applying imiquimod cream.

Cut the top off the sachet or pierce the sachet with a needle and squeeze out a tiny amount of cream onto your fingertip. Apply this to the affected areas.

Although the information on the packet states that the sachet is for single use, you could seal it using a paper clip or tape and store in a closed container to prevent the cream drying out.

Imiquimod may be used at any time of year, as it is not photosensitising. However, when outdoors, you should protect yourself from the sun with clothing and sunscreen as usual.

If you are using imiquimod in the genital area, wash it off before having sexual intercourse. It can also weaken condoms.

What to expect from imiquimod cream

Areas treated with imiquimod will be come inflamed. The effects include itching, burning, redness, ulceration (sores), scabbing, flaking and pain. These reactions indicate that the cream is likely to be effective - if there is no inflammation, imiquimod is unlikely to clear the lesions. An exaggerated response may clear the skin lesion sooner than expected — sometimes after as few as three or four applications. In some patients, surrounding untreated areas also become inflamed but this will settle when treatment is discontinued.

If you develop a severe reaction with black scabs and ulceration, stop applying the cream and arrange to see your doctor as soon as possible.

More images of the effect of imiquimod ...

Systemic side effects from imiquimod cream

When using imiquimod cream, 'flu-like symptoms may develop, such as fever, fatigue, headache, nausea, diarrhoea and muscle pain. These are generally mild and may be treated with paracetamol. However, if they are troublesome, stop applying imiquimod cream and contact your doctor. Side effects should resolve within a few days of stopping treatment. They may also resolve with continuing treatment.

Make sure you have made an appointment for follow-up with your doctor.