Skin signs of respiratory disease

Author(s): Dr Kate Dear, Senior House Officer, St Mary’s Hospital, London, United Kingdom. DermNet New Zealand Editor in Chief: A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Copy editor: Gus Mitchell, November 2017.

What is respiratory disease?

Respiratory disease refers to any condition that affects the upper respiratory tract, trachea, lungs, and the nerves and muscles associated with breathing. The correct recognition of cutaneous signs of respiratory disease can aid clinicians to diagnose and treat these potentially life–threatening diseases.

What are the skin signs of respiratory disease?


Cyanosis is a blue discolouration of skin and mucous membranes. It is seen in patients with more than 5 g/dL of desaturated haemoglobin. Cyanosis may be:

  • Central — on the lips/tongue; relates to a circulatory or ventilatory problem associated with poor blood oxygenation in the lungs
  • Peripheral — on the extremities or fingers; due to oxygen–depleted peripheral blood

Nail clubbing

Nail clubbing is a deformity of the nails characterised by:

  • Loss of the Lovibond angle of the nail bed and the nail fold
  • Thickening of the end of the finger
  • Increase in nail fold convexity
  • Soft boggy nail texture [1]. 

Clubbing is associated with a wide range of diseases, including the following respiratory diseases:

  • Lung cancer
  • Interstitial lung disease, most commonly fibrosing alveolitis
  • Tuberculosis
  • Cystic fibrosis
  • Suppurative (pus forming) lung disease, such as lung abscess, empyema, bronchiectasis
  • Mesothelioma (tumour of the lining of the lung)
  • Arteriovenous fistula/malformation (abnormal formation or connection between arteries and veins).

Hypertrophic osteoarthropathy

Hypertrophic osteoarthropathy comprises:

  • Clubbing of the fingers
  • Periostitis (inflammation of the layer of connective tissue around a bone)
  • Arthritis (inflammation of a joint).

Symptoms of hypertrophic osteoarthropathy may precede the diagnosis of lung cancer and is most commonly associated with non–small lung cancer, particularly squamous cell carcinoma and adenocarcinoma [3]. Hypertrophic osteoarthropathy can also be secondary to lung abscess, mesothelioma and other disorders [1].


Lung cancer

Cutaneous metastases in lung cancer are found in 2–8% of cases of lung cancer [1]. The most common sites are the chest and abdominal wall, neck and scalp. They are usually rapidly growing, hard, painless and mobile nodules. A punch biopsy of a nodule may be nonspecific or may establish the diagnosis of lung cancer.

Monitoring changes in the size of skin nodules can help assess response to chemotherapy [1]. Other cutaneous manifestations of lung cancer include:

Cutaneous signs of lung cancer

Superior vena cava syndrome

Superior vena cava syndrome is due to obstruction of the superior vena cava. The majority of cases are due to malignancy, most commonly non–small cell lung cancer, small-cell lung cancer, lymphoma and metastatic tumours [4]. Superior vena cava syndrome presents with markedly dilated veins or venules in the upper chest [5]. These occur as a result of increased collateral flow through the superficial vasculature in the chest wall.


Sarcoidosis can be divided into two separate conditions:

  1. A multisystem disease, with 30% of patients having cutaneous involvement [6]
  2. Cutaneous sarcoidosis, in which there is no systemic involvement [7].

Cutaneous involvement is classified as either specific, in which there are non–caseating granulomas on histopathology, or nonspecific, in which granulomas are absent.

Specific lesions of sarcoidosis include:

Non–specific lesions of sarcoidosis include:

Cutaneous sarcoidosis

Cystic fibrosis

Cutaneous manifestations of cystic fibrosis may be nonspecific, but include:

  • Aquagenic skin wrinkling (due to increased concentration of electrolytes in the sweat)
  • Cutaneous vasculitis (due to circulating immune complexes; antigens are bacteria, antibiotics and pancreatic enzyme supplements)
  • Cystic fibrosis nutrient deficiency dermatitis [9].
Cutaneous signs of cystic fibrosis

Granulomatosis with polyangiitis

Cutaneous manifestations of granulomatosis with polyangiitis (also known as Wegener granulomatosis) are found in 10% of patients at diagnosis, and develop in 50% of patients throughout the course of the disease [1,8].

Skin findings include:

Cutaneous signs of granulomatosis with polyangiitis

Eosinophilic granulomatosis with polyangiitis

Eosinophilic granulomatosis with polyangiitis (also known as Churg-Strauss syndrome) is a rare multisystem disorder that primarily affects the lungs, skin and peripheral nervous system. The main features are asthma, eosinophil infiltration in the lungs and blood, and small vessel vasculitis with granulomas (mixed chronic inflammatory cells) on biopsy.

A variety of skin lesions are seen in eosinophilic granulomatosis with polyangiitis:

Papules and nodules may become necrotic, starting with a central black dimple.  

Vasculitis in eosinophilic granulomatosis

Pulmonary arteriovenous malformations

Pulmonary arteriovenous malformations are abnormal communications between the arteries and veins that supply the lungs. The majority of these malformations are congenital. Approximately 70% of patients with pulmonary arteriovenous malformations have associated hereditary haemorrhagic telangiectasia (also known as Osler–Weber–Rendu syndrome) in which there are small, dilated blood vessels (telangiectasia) near the surface of the skin. These most commonly affect face, hands, feet, chest, lips, tongue, oral mucosa, and nasal mucosa [1].

Alpha–1–antitrypsin deficiency

Alpha–1–antitrypsin deficiency is a genetic disorder in which there is defective production of the alpha–1 antitrypsin enzyme. It primarily affects the lungs (with emphysema), liver and skin. Cutaneous findings include recurrent ulcerative, necrotising panniculitis (crops of painful, red subcutaneous nodules), which most noticeably occur on the trunk and proximal extremities. These nodules typically ulcerate, releasing a clear to yellow oily fluid [1].

Fat embolism syndrome

Fat embolism syndrome typically follows fractures and trauma to the long bones or pelvis. Fat particles released into the circulation may cause:

  • Respiratory distress
  • Altered mental status
  • Thrombocytopenia.

The classic cutaneous manifestation of fat embolism syndrome is a petechial eruption with 2–3 mm purpuric macules on nondependent portions of the body (upper chest, neck, axillae and conjunctivae). This finding often disappears within 5–7 days, but may be key for diagnosis [10,11].

Yellow nail syndrome

Yellow nail syndrome is the triad of:

  1. Yellow nails
  2. Lymphoedema (swelling caused by blockage of the lymphatic system)
  3. Pleural effusions (fluid in the space surrounding the lungs) [8].

Nail changes that are usually the first features of yellow nail syndrome include:

  • Onycholysis (separation of the nail from the nail bed)
  • Transverse ridging on a smooth base
  • Loss of the cuticle
  • Slow growth (less than half the rate of healthy nails) [7].

The nails are occasionally green in colour. Lymphoedema associated with yellow nail syndrome typically affects the legs and is symmetrical and non–pitting.  

Yellow nail syndrome

Birt–Hogg–Dube syndrome

Birt–Hogg–Dubé syndrome is an autosomal dominant inherited disease characterised by skin tumours, pneumothoraces (lung collapse), kidney tumours, and lung cysts [12].

Cutaneous lesions include:

Fibrofolliculomas and trichodiscomas are most frequently found on the head, face and upper body.

  • They are asymptomatic pale yellow, slightly raised, dome–shaped papules measuring 2–4 mm in diameter.
  • There may be few or many hundreds of lesions.  
  • They usually develop at around 30–40 years of age [1].
Trichofolliculomas in Birt-Hogg-Dubé syndrome


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Related information



  1. Kaldas M. Dermatologic manifestations of pulmonary disease. Medscape. Jan 2015. 
  2. Owen C. Cutaneous manifestations of lung cancer. Seminars in Oncology 2016; 43 (3): 366–369. DOI: 10.1053/j.seminoncol.2016.02.025. PubMed
  3. Davis M, Sherry V. Hypertrophic osteoarthropathy as a clinical manifestation of lung cancer. Clin J Oncol Nurs 2011; 15 (5): 561–3. PubMed
  4. Wilson L, Detterbeck F, Yahalom J. Superior Vena Cava Syndrome with Malignant Causes. N Engl J Med 2007; 356: 1862–69. DOI: 10.1056/NEJMcp067190 PubMed
  5. Ratnarathorn M. Cutaneous findings leading to a diagnosis of superior vena cava syndrome: A case report and review of the literature. Dermatology Online Journal 2011; 17 (6): 4. PubMed
  6. Noe M, Rosenbach M. Cutaneous sarcoidosis. Current Opinion in Pulmonary Medicine 2017. DOI: 10.1097/MCP.0000000000000402. PubMed
  7. Soutor C, Hordinsky M. Clinical dermatology, 1st edn. London: McGraw Hill, 2013.
  8. Weller R. Clinical dermatology, 5th edn. Oxford: John Wiley & Sons, 2015.
  9. Rullán, J, Seijo–Montes E, Vaillant A. Cutaneous manifestations of pulmonary disease. In: Sánchez N (ed). Atlas of dermatology in Internal Medicine. New York: Springer, 2012: 19–29.
  10. Aparicio G, Soler I, López–Durán L. Fat embolism syndrome after nailing an isolated open tibial fracture in a stable patient: a case report. BMC Res Notes 2014; 7: 237
  11. Kosova E, Bergmark B, Piazza G. Fat embolism syndrome. Circulation 2015; 131(3), 317–320.
  12. Habif T, 6th edn. Clinical dermatology: a colour guide to diagnosis and therapy. St Louis: Saunders, 2016.

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